Name | Larsson Nils-Göran, Dr. |
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Institution | Department of Medical Biochemistry and Biophysics,
Division of Molecular Metabolism, Karolinska Institutet, Karolinska University Hospital, SE |
Address | Solnavägen 9, 171 65 |
City | Stockholm |
State/Province | |
Country | Sweden |
[email protected] | |
Weblink | https://ki.se/en/mbb/people-nils-goran-larsson-group |
O2k-Network Lab | SE Stockholm Larsson NG |
Labels:
Publications
Published | Reference | |
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Jiang 2024 Nat Metab | 2024 | Jiang S, Yuan T, Rosenberger FA, Mourier A, Dragano NRV, Kremer LS, Rubalcava-Gracia D, Hansen FM, Borg M, Mennuni M, Filograna R, Alsina D, Misic J, Koolmeister C, Papadea P, de Angelis MH, Ren L, Andersson O, Unger A, Bergbrede T, Di Lucrezia R, Wibom R, Zierath JR, Krook A, Giavalisco P, Mann M, Larsson NG (2024) Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nat Metab [Epub ahead of print]. https://doi.org/10.1038/s42255-024-01038-3 |
Silva Ramos 2019 PLoS Genet | 2019 | Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A (2019) Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15:e1008085. |
Jiang 2019 EMBO Rep | 2019 | Jiang S, Koolmeister C, Misic J, Siira S, Kühl I, Silva Ramos E, Miranda M, Jiang M, Posse V, Lytovchenko O, Atanassov I, Schober FA, Wibom R, Hultenby K, Milenkovic D, Gustafsson CM, Filipovska A, Larsson NG (2019) TEFM regulates both transcription elongation and RNA processing in mitochondria. EMBO Rep 20:e48101. |
Perks 2018 Cell Rep | 2018 | Perks KL, Rossetti G, Kuznetsova I, Hughes LA, Ermer JA, Ferreira N, Busch JD, Rudler DL, Spahr H, Schöndorf T, Shearwood AJ, Viola HM, Siira SJ, Hool LC, Milenkovic D, Larsson NG, Rackham O, Filipovska A (2018) PTCD1 is required for 16S rRNA maturation complex stability and mitochondrial ribosome assembly. Cell Rep 23:127-42. |
Kauppila 2018 Nucleic Acids Res | 2018 | Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG (2018) Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res 46:6642-69. |
Richman 2016 Nat Commun | 2016 | Richman TR, Spåhr H, Ermer JA, Davies SM, Viola HM, Bates KA, Papadimitriou J, Hool LC, Rodger J, Larsson NG, Rackham O, Filipovska A (2016) Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Nat Commun 7:11884. |
Rackham 2016 Cell Rep | 2016 | Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A (2016) Hierarchical RNA processing is required for mitochondrial ribosome assembly. Cell Rep 16:1874-90. |
Silva Ramos 2016 Biochim Biophys Acta | 2016 | Silva Ramos E, Larsson NG, Mourier A (2016) Bioenergetic roles of mitochondrial fusion. Biochim Biophys Acta 1857:1277-83. |
Mourier 2015 J Cell Biol | 2015 | Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG (2015) Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol 208:429-42. |
Bratic 2015 Nat Commun | 2015 | Bratic A, Kauppila TE, Macao B, Grönke S, Siibak T, Stewart JB, Baggio F, Dols J, Partridge L, Falkenberg M, Wredenberg A, Larsson NG (2015) Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies. Nat Commun 6:8808. |
Mourier 2014 Hum Mol Genet | 2014 | Mourier A, Ruzzenente B, Brandt T, Kühlbrandt W, Larsson NG (2014) Loss of LRPPRC causes ATP synthase deficiency. Hum Mol Genet 23:2580-92. |
Bratic 2013 J Clin Invest | 2013 | Bratic A, Larsson NG (2013) The role of mitochondria in aging. J Clin Invest 123:951-7. |
Wredenberg 2013 PLoS Genet | 2013 | Wredenberg A, Lagouge M, Bratic A, Metodiev MD, Spåhr H, Mourier A, Freyer C, Ruzzenente B, Tain L, Grönke S, Baggio F, Kukat C, Kremmer E, Wibom R, Polosa PL, Habermann B, Partridge L, Park CB, Larsson NG (2013) MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals. PLoS Genet 9:e1003178. |
Freyer 2012 Nat Genet | 2012 | Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Floros VI, Hagström E, Chatzidaki EE, Wiesner RJ, Samuels DC, Larsson NG, Chinnery PF (2012) Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nat Genet 44:1282-5. |
Bratic 2011 PLoS Genet | 2011 | Bratic A, Wredenberg A, Grönke S, Stewart JB, Mourier A, Ruzzenente B, Kukat C, Wibom R, Habermann B, Partridge L, Larsson NG (2011) The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster. PLoS Genet 7:e1002324. |
Freyer 2010 Nucleic Acids Res | 2010 | Freyer C, Park CB, Ekstrand MI, Shi Y, Khvorostova J, Wibom R, Falkenberg M, Gustafsson CM, Larsson NG (2010) Maintenance of respiratory chain function in mouse hearts with severely impaired mtDNA transcription. Nucleic Acids Res 38:6577–88. |
Abstracts
Published | Reference | |
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Felser 2014 Abstract MiP2014 | 2014 | Assessing mitochondrial dysfunction in fibroblast cells – a comparison between O2k and multiwell respirometry. |
Brandt 2013 Abstract MiP2013 | 2013 | Brandt T, Mourier A, Stewart JB, Larsson NG, Kühlbrandt W (2013) Structure and function of aged mouse mitochondria. Mitochondr Physiol Network 18.08. |