Hroudova 2013 Mitochondrion

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Publications in the MiPMap
HroudovΓ‘ J, FiΕ‘ar Z, KitzlerovΓ‘ E, ZvΔ›Ε™ovΓ‘ M, Raboch J (2013) Mitochondrial respiration in blood platelets of depressive patients. Mitochondrion 13:795-800.

Β» PMID: 23688905

Hroudova J, Fisar Z, Kitzlerova E, Zverova M, Raboch J (2013) Mitochondrion

Abstract: Recent evidences include mitochondrial dysfunctions in pathophysiology of mood disorders. We examined association between depressive disorders and mitochondrial respiration using both living and permeabilized blood platelets. In living platelets, physiological respiration, maximal capacity of electron transport system and respiratory rate after Complex I inhibition were decreased in depressive patients, who reached partial remission, compared to healthy controls. Respiratory rates were unchanged in several respiratory states in permeabilized platelets. Results indicate that changes in respiratory rate in living platelets can be used as biological marker of depressive disorder. Hypothesis was supported that decreased mitochondrial respiratory rate participate in pathophysiology of depression. β€’ Keywords: Blood platelet, Depressive disorder, Mitochondrion, Respiratory rate

β€’ O2k-Network Lab: CZ Prague Fisar Z

Labels: MiParea: Respiration, mt-Medicine  Pathology: Neurodegenerative  Stress:Mitochondrial disease  Organism: Human  Tissue;cell: Blood cells, Platelet  Preparation: Permeabilized cells, Intact cells 

Coupling state: LEAK, ROUTINE, OXPHOS, ET  Pathway: N, S, NS, ROX  HRR: Oxygraph-2k 

MitoEAGLE blood cells data 

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