Holzner 2019 MitoFit Preprint Arch EA

From Bioblast

MitoFit Preprints         MitoFit Preprints        
Gnaiger 2019 MitoFit Preprints
Gnaiger MitoFit Preprints 2020.4
        MitoFit DOI Data Center         MitoPedia: Preprints         Bioenergetics Communications

Holzner 2019 MitoFit Preprint Arch EA

Publications in the MiPMap
Holzner Lorenz MW, Sowton AP, Murray AJ (2019) Evidence of altered mitochondrial function in glycolytic, but not oxidative skeletal muscle in mice after one month of high fat, high sucrose feeding. https://doi.org/10.26124/mitofit:ea19.MiPSchool.0004

Β» MitoFit Preprint Arch EA19.4.

MitoFit pdf

Evidence of altered mitochondrial function in glycolytic but not oxidative skeletal muscle in mice after one month of high fat high sucrose feeding

Holzner Lorenz MW, Sowton AP, Murray AJ (2019) MitoFit Preprint Arch

Abstract: Version 1 (v1) 2019-06-11 doi:10.26124/mitofit:ea19.MiPSchool.0004

Rates of obesity and the metabolic syndrome, which are strongly associated with type 2 diabetes (T2D) and cardiovascular disease, continue to rise worldwide. Skeletal muscle is an important tissue in the development of these disorders, as it serves as the major β€œglucose sink” in the body, and skeletal muscle mitochondrial dysfunction occurs in both metabolic syndrome and T2D [1]. Understanding of the early processes involved in skeletal muscle dysfunction, including changes in mitochondrial function, is currently lacking. It has been proposed that greater mitochondrial oxidation capacity, as is the case in oxidative muscles such as the soleus, can allay the onset of mitochondrial dysfunction induced by high fat, high sugar (HFHS) feeding. Previous studies in fructose fed rats appear to support this view [2]. If this is the case, soleus muscle may be less likely to develop mitochondrial dysfunction than a more glycolytic muscle, such as the gastrocnemius, when exposed to short term HFHS feeding. Here we investigated effect of HFHS feeding over one month on skeletal muscle oxidative capacity, comparing respiration in soleus and gastrocnemius fibres. β€’ Keywords: Diabetes & [https://wiki.oroboros.at/index.php/O2k-Publications:_Skeletal_muscle β€’ Bioblast editor: Iglesias-Gonzalez J β€’ O2k-Network Lab: UK Cambridge Murray AJ


Holzner Lorenz MW(1), Sowton AP(2), Murray AJ(1)

  1. Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge - [email protected]
  2. Department of Physiology, Development and Neuroscience, University of Cambridge


Holzner 2019 MitoFit Preprint Arch EA Figure 1.png
Holzner 2019 MitoFit Preprint Arch EA Figure 2.png


  1. Thyfault JP, Kraus RM, Hickner RC, Howell AW, Wolfe RR, Dohm GL (2004) "Impaired plasma fatty acid oxidation in extremely obese women," Am J Physiol Endocrinol Metab 287(6):1076-81
  2. Warren BE, Lou PH, Lucchinetti E, Zhang L, Clanachan AS, Affolter A, Hersberger M, Zaugg M, Lemieux H (2014), "Early mitochondrial dysfunction in glycolytic muscle, but not oxidative muscle, of the fructose-fed insulin-resistant rat," Am J Physiol Endocrinol Metab, 306(6):658-67
  3. Horscroft JA, O'Brien KA, Clark AD, Lindsay RT, Steel AS, Procter NEK, Devaux J, Frenneaux M, Harridge SDR, Murray AJ (2019) "Inorganic nitrate, hypoxia, and the regulation of cardiac mitochondrial respirationβ€”probing the role of PPARΞ±," FASEB J, 33


Β» MiPschool Coimbra 2019

Preprints for Gentle Science

MitoFit Preprints.png

Β» MitoFit Preprints - the Open Access preprint server for mitochondrial physiology and bioenergetics

Β» MitoPedia: Preprints



Cookies help us deliver our services. By using our services, you agree to our use of cookies.