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Gvozdjakova 2022 Environ Sci Pollut Res Int

From Bioblast
Publications in the MiPMap
Gvozdjáková A, Sumbalová Z, Kucharská J, Rausová Z, Kovalčíková E, Takácsová T, Navas P, López-Lluch G, Mojto V, Palacka P (2022) Mountain spa rehabilitation improved health of patients with post-COVID-19 syndrome: pilot study.

» Environ Sci Pollut Res Int 30:14200-211. PMID: 36151435 Open Access

Gvozdjakova Anna, Sumbalova Zuzana, Kucharska Jarmila, Rausova Zuzana, Kovalcikova Eleonora, Takacsova Timea, Navas Placido, Lopez-Lluch Guillermo, Mojto Viliam, Palacka Patrik (2022) Environ Sci Pollut Res Int

Abstract: European Association of Spa Rehabilitation (ESPA) recommends spa rehabilitation for patients with post-COVID-19 syndrome. We tested the hypothesis that a high-altitude environment with clean air and targeted spa rehabilitation (MR - mountain spa rehabilitation) can contribute to the improving platelet mitochondrial bioenergetics, to accelerating patient health and to the reducing socioeconomic problems. Fifteen healthy volunteers and fourteen patients with post-COVID-19 syndrome were included in the study. All parameters were determined before MR (MR1) and 16-18 days after MR (MR2). Platelet mitochondrial respiration and OXPHOS were evaluated using high resolution respirometry method, coenzyme Q10 level was determined by HPLC, and concentration of thiobarbituric acid reactive substances (TBARS) as a parameter of lipid peroxidation was determined spectrophotometrically. This pilot study showed significant improvement of clinical symptoms, lungs function, and regeneration of reduced CI-linked platelet mitochondrial respiration after MR in patients with post-COVID-19 syndrome. High-altitude environment with spa rehabilitation can be recommended for the acceleration of recovery of patients with post-COVID-19 syndrome. Keywords: Clinical symptoms, Coenzyme Q10, High-altitude environment, Mountain spa rehabilitation, Oxidative stress, Platelet mitochondrial metabolism, Post-COVID-19 syndrome Bioblast editor: Plangger M O2k-Network Lab: SK Bratislava Sumbalova Z

Labels: MiParea: Respiration, Patients 

Organism: Human  Tissue;cell: Platelet  Preparation: Permeabilized cells, Intact cells 

Coupling state: LEAK, ROUTINE, OXPHOS, ET  Pathway: N, NS  HRR: Oxygraph-2k