Fliri 2015 US Patent

From Bioblast
Publications in the MiPMap
Fliri HG, Ford RL, Scowen DA, Batcheller DG, Ehinger J, ElmΓ©r E, Hansson MJ, SjΓΆvall F (2015) Protected succinates for enhancing mitochondrial atp-production. US Patent US20150259317 A1.

Β» Open Access

Fliri HG, Ford RL, Scowen DA, Batcheller DG, Ehinger J, Elmer E, Hansson MJ, Sjoevall F (2015) US Patent

Abstract: Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. The compounds may be of formula (I) wherein R1 is H or an optionally substituted alkyl group or a group of formula (II) and R2 is independently a group according to formula (II) where formula (II) is as defined 10 herein.

β€’ Bioblast editor: Kandolf G β€’ O2k-Network Lab: SE Lund Elmer E

Labels: MiParea: Respiration, Pharmacology;toxicology 

Organism: Human  Tissue;cell: Blood cells, Platelet  Preparation: Intact cells, Permeabilized cells 

Coupling state: ET  Pathway: S, NS, ROX  HRR: Oxygraph-2k 


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