Colin 2021 J Cell Mol Med
| Colin M, Dechene L, Ceusters J, Niesten A, Demazy C, Lagneaux L, Zouaoui Boudjeltia K, Franck T, Van Antwerpen P, Renard P, Mathieu V, Serteyn D (2021) Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell-based therapy development. J Cell Mol Med 25:4877-81. |
Colin Margaux, Dechene Lola, Ceusters Justine, Niesten Ariane, Demazy Catherine, Lagneaux Laurence, Zouaoui Boudjeltia Karim, Franck Thierry, Van Antwerpen Pierre, Renard Patricia, Mathieu Veronique, Serteyn Didier (2021) J Cell Mol Med
Abstract: Mesenchymal stem cells are increasingly studied for their use as drug-carrier in addition to their intrinsic potential for regenerative medicine. They could be used to transport molecules with a poor bioavailability such as curcumin in order to improve their clinical usage. This natural polyphenol, well-known for its antioxidant and anti-inflammatory properties, has a poor solubility that limits its clinical potential. For this purpose, the use of NDS27, a curcumin salt complexed with hydroxypropyl-beta-cyclodextrin (HPΞ²CD), displaying an increased solubility in aqueous solution, is preferred. This study aims to evaluate the uptake of NDS27 into skeletal muscle-derived mesenchymal stem cells (mdMSCs) and the effects of such uptake onto their mesenchymal properties. It appeared that the uptake of NDS27 into mdMSCs is concentration-dependent and not time-dependent. The use of a concentration of 7 Β΅mol/L which does not affect the viability and proliferation also allows preservation of their adhesion, invasion and T cell immunomodulatory abilities. β’ Keywords: NDS27, Curcumin, Cyclodextrin, Equine MSCs, mdMSC, Mesenchymal stem cells, Mitochondria β’ Bioblast editor: Reiswig R β’ O2k-Network Lab: BE Liege Votion DM
Labels: MiParea: Respiration, Pharmacology;toxicology
Organism: Horse
Tissue;cell: Stem cells
Preparation: Intact cells
Coupling state: LEAK, OXPHOS, ET
Pathway: N, S, NS
HRR: Oxygraph-2k
2021-08
