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Colin 2021 J Cell Mol Med

From Bioblast
Publications in the MiPMap
Colin M, Dechene L, Ceusters J, Niesten A, Demazy C, Lagneaux L, Zouaoui Boudjeltia K, Franck T, Van Antwerpen P, Renard P, Mathieu V, Serteyn D (2021) Priming of mesenchymal stem cells with a hydrosoluble form of curcumin allows keeping their mesenchymal properties for cell-based therapy development. J Cell Mol Med 25:4877-81.

» PMID: 33769687 Open Access

Colin Margaux, Dechene Lola, Ceusters Justine, Niesten Ariane, Demazy Catherine, Lagneaux Laurence, Zouaoui Boudjeltia Karim, Franck Thierry, Van Antwerpen Pierre, Renard Patricia, Mathieu Veronique, Serteyn Didier (2021) J Cell Mol Med

Abstract: Mesenchymal stem cells are increasingly studied for their use as drug-carrier in addition to their intrinsic potential for regenerative medicine. They could be used to transport molecules with a poor bioavailability such as curcumin in order to improve their clinical usage. This natural polyphenol, well-known for its antioxidant and anti-inflammatory properties, has a poor solubility that limits its clinical potential. For this purpose, the use of NDS27, a curcumin salt complexed with hydroxypropyl-beta-cyclodextrin (HPβCD), displaying an increased solubility in aqueous solution, is preferred. This study aims to evaluate the uptake of NDS27 into skeletal muscle-derived mesenchymal stem cells (mdMSCs) and the effects of such uptake onto their mesenchymal properties. It appeared that the uptake of NDS27 into mdMSCs is concentration-dependent and not time-dependent. The use of a concentration of 7 µmol/L which does not affect the viability and proliferation also allows preservation of their adhesion, invasion and T cell immunomodulatory abilities. Keywords: NDS27, Curcumin, Cyclodextrin, Equine MSCs, mdMSC, Mesenchymal stem cells, Mitochondria Bioblast editor: Reiswig R O2k-Network Lab: BE Liege Votion DM

Labels: MiParea: Respiration, Pharmacology;toxicology 

Organism: Horse  Tissue;cell: Stem cells  Preparation: Intact cells 

Coupling state: LEAK, OXPHOS, ET  Pathway: N, S, NS  HRR: Oxygraph-2k