Chin 2015 US Patent
| Chin MT, Chien WM, Dinca A (2015) Modified tafazzin proteins and methods of making and using the same. US Patent US20150203827 A1. |
Chin MT, Chien WM, Dinca A (2015) US Patent
Abstract: Fusion proteins comprising a tafazzin peptide and a cellular permeability peptide are disclosed. The tafazzin peptide may be coupled to the permeability peptide through a polypeptide linker. Methods of making and using the fusion proteins are also disclosed. For example, the disclosed fusion proteins may be used to treat a patient having a disorder associated with a tafazzin deficiency or a remodeled cardiolipin deficiency (e.g., Barth syndrome). Additionally, the disclosed fusion proteins may be used in prophylaxis against developing a disorder associated with a tafazzin deficiency or a remodeled cardiolipin deficiency in a patient at risk of developing such a disorder.
• Bioblast editor: Kandolf G
Labels: MiParea: Respiration
Organism: Mouse
Tissue;cell: Skeletal muscle
Preparation: Permeabilized tissue
Coupling state: OXPHOS
Pathway: N, S, CIV
HRR: Oxygraph-2k
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