Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Charles 2020 Nanomedicine (Lond)

From Bioblast
Publications in the MiPMap
Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) 15:2917-32.

Β» PMID: 33241963

Charles Carleigh, Cohen-Erez Ifat, Kazaoka Blake, Melnikov Olga, Stein David E, Sensenig Richard, Rapaport Hanna, Orynbayeva Zulfiya (2020) Nanomedicine (Lond)

Abstract: The mechanistic study of the drug carrier-target interactions of mitochondria-unique nanoparticles composed of polypeptide-peptide complexes (mPoP-NPs).

The isolated organelles were employed to address the direct effects of mPoP-NPs on dynamic structure and functional wellbeing of mitochondria. Mitochondria morphology, respiration, membrane potential, reactive oxygen species generation, were examined by confocal microscopy, flow cytometry and oxygraphy. Lonidamine-encapsulated formulation was assessed to evaluate the drug delivery capacity of the naive nanoparticles.

The mPoP-NPs do not alter mitochondria structure and performance upon docking to organelles, while successfully delivering drug that causes organelle dysfunction.

The study gives insight into interactions of mPoP-NPs with mitochondria and provides substantial support for consideration of designed nanoparticles as biocompatible and efficient mitochondria-targeted platforms. β€’ Keywords: OxPhos, TPP+, Cancer, Ionidamine, Membrane potential, Mitochondria, Nanoparticles β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: US PA Philadelphia Orynbayeva Z

Labels: MiParea: Respiration, mt-Structure;fission;fusion, Pharmacology;toxicology 

Organism: Human  Tissue;cell: Endothelial;epithelial;mesothelial cell  Preparation: Isolated mitochondria 

Regulation: mt-Membrane potential  Coupling state: LEAK, OXPHOS  Pathway: N, S, CIV, ROX  HRR: Oxygraph-2k, O2k-Fluorometer, TPP 

2020-12, AmR