Cecatto 2020 Mitochondrion

From Bioblast
Publications in the MiPMap
Cecatto C, Amaral AU, Wajner A, Wajner SM, Castilho RF, Wajner M (2020) Disturbance of mitochondrial functions associated with permeability transition pore opening induced by cis-5-tetradecenoic and myristic acids in liver of adolescent rats. Mitochondrion 50:1-13.

Β» PMID: 31655165 Open Access

Cecatto C, Amaral AU, Wajner A, Wajner SM, Castilho RF, Wajner M (2020) Mitochondrion

Abstract: Patients affected by very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency commonly present liver dysfunction whose pathogenesis is poorly known. We demonstrate here that major metabolites accumulating in this disorder, namely cis-5-tetradecenoic acid (Cis-5) and myristic acid (Myr), markedly impair mitochondrial respiration, decreasing ATP production in liver mitochondrial preparations from adolescent rats. Other parameters of mitochondrial homeostasis such as membrane potential (ΔΨm) and Ca2+retention capacity were strongly compromised by these fatty acids, involving induction of mitochondrial permeability transition. The present data indicate that disruption of mitochondrial bioenergetics and Ca2+homeostasis may contribute to the liver dysfunction of VLCAD deficient patients.

Copyright Β© 2019 Elsevier B.V. and Mitochondria Research Society. All rights reserved. β€’ Keywords: Cis-5-tetradecenoic acid, Liver mitochondria, Mitochondrial homeostasis, Mitochondrial permeability transition, Myristic acid, VLCAD deficiency β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: BR Porto Alegre Souza DOG

Labels: MiParea: Respiration, Pharmacology;toxicology  Pathology: Inherited, Other  Stress:Permeability transition  Organism: Rat  Tissue;cell: Liver, Other cell lines  Preparation: Permeabilized cells, Isolated mitochondria 

Regulation: Calcium, mt-Membrane potential, Fatty acid  Coupling state: LEAK, OXPHOS, ET  Pathway: N, S  HRR: Oxygraph-2k 

Labels, 2019-11 

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