Cardinale 2018 Front Physiol

From Bioblast
Publications in the MiPMap
Cardinale DA, Larsen FJ, Schiffer TA, Morales-Alamo D, Ekblom B, Calbet JAL, Holmberg HC, Boushel R (2018) Superior intrinsic mitochondrial respiration in women than in men. Front Physiol 9:1133.

Β» PMID: 30174617 Open Access

Cardinale Daniele A, Larsen Filip J, Schiffer Tomas A, Morales-Alamo David, Ekblom Bjoern, Calbet Jose AL, Holmberg Hans-Christer, Boushel Robert C (2018) Front Physiol

Abstract: Sexual dimorphism is apparent in humans, however, to date no studies have investigated mitochondrial function focusing on intrinsic mitochondrial respiration (i.e., mitochondrial respiration for a given amount of mitochondrial protein) and mitochondrial oxygen affinity (p50mito) in relation to biological sex in human. A skeletal muscle biopsy was donated by nine active women, and ten men matched for maximal oxygen consumption (VO2max) and by nine endurance trained men. Intrinsic mitochondrial respiration, assessed in isolated mitochondria, was higher in women compared to men when activating Complex I (CIP) and Complex I+II (CI+IIP) (p < 0.05), and was similar to trained men (CIP, p = 0.053; CI+IIP, p = 0.066). Proton leak and p50mito were higher in women compared to men independent of VO2max. In conclusion, significant novel differences in mitochondrial oxidative function, intrinsic mitochondrial respiration and p50mito exist between women and men. These findings may represent an adaptation in the oxygen cascade in women to optimize muscle oxygen uptake to compensate for a lower oxygen delivery during exercise. β€’ Keywords: OXPHOS, Endurance performance, Mitochondria, Mitochondrial function, Sexual dimorphism, Skeletal muscle β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: SE Stockholm Larsen FJ, SE Uppsala Liss P, SE Stockholm Boushel RC, SE Stockholm Cardinale DA

Labels: MiParea: Respiration, Gender, Exercise physiology;nutrition;life style 

Organism: Human  Tissue;cell: Skeletal muscle  Preparation: Isolated mitochondria 

Regulation: Oxygen kinetics  Coupling state: OXPHOS  Pathway: F, N, NS  HRR: Oxygraph-2k 

Labels, 2018-09, VO2max, Alert2020 

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