Cardinale 2018 Front Physiol

Cardinale DA, Larsen FJ, Schiffer TA, Morales-Alamo D, Ekblom B, Calbet JAL, Holmberg HC, Boushel R (2018) Superior intrinsic mitochondrial respiration in women than in men. Front Physiol 9:1133.

» PMID: 30174617 Open Access

Cardinale Daniele A, Larsen Filip J, Schiffer Tomas A, Morales-Alamo David, Ekblom Bjoern, Calbet Jose AL, Holmberg Hans-Christer, Boushel Robert C (2018) Front Physiol

Abstract: Sexual dimorphism is apparent in humans, however, to date no studies have investigated mitochondrial function focusing on intrinsic mitochondrial respiration (i.e., mitochondrial respiration for a given amount of mitochondrial protein) and mitochondrial oxygen affinity (p_50mito) in relation to biological sex in human. A skeletal muscle biopsy was donated by nine active women, and ten men matched for maximal oxygen consumption (V_O₂max) and by nine endurance trained men. Intrinsic mitochondrial respiration, assessed in isolated mitochondria, was higher in women compared to men when activating Complex I (CI_P) and Complex I+II (CI+II_P) (p < 0.05), and was similar to trained men (CI_P, p = 0.053; CI+II_P, p = 0.066). Proton leak and p_50mito were higher in women compared to men independent of V_O₂max. In conclusion, significant novel differences in mitochondrial oxidative function, intrinsic mitochondrial respiration and p_50mito exist between women and men. These findings may represent an adaptation in the oxygen cascade in women to optimize muscle oxygen uptake to compensate for a lower oxygen delivery during exercise. • Keywords: OXPHOS, Endurance performance, Mitochondria, Mitochondrial function, Sexual dimorphism, Skeletal muscle • Bioblast editor: Plangger M • O2k-Network Lab: SE Stockholm Larsen FJ, SE Uppsala Liss P, SE Stockholm Boushel RC, SE Stockholm Cardinale DA

Labels: MiParea: Respiration, Gender, Exercise physiology;nutrition;life style

Organism: Human Tissue;cell: Skeletal muscle Preparation: Isolated mitochondria

Regulation: Oxygen kinetics Coupling state: OXPHOS Pathway: F, N, NS HRR: Oxygraph-2k

Labels, 2018-09, VO2max, Alert2020