Barbieri 2015 Abstract MiPschool London 2015
|Mitochondria remodelling in hypoxia.|
Event: MiPschool London 2015
One of the major challenging conditions cancer and cancer stem/progenitor cells face in situ is the adaptation and the survival in an environment characterized by continuously floating pO2. Many of the features of the adaptation to hypoxia are mastered by hypoxia inducible factor 1α (HIF1α) that prompts glycolysis, increases the efficiency of mitochondrial O2 consumption and autophagy to sustain biosynthesis. Mitochondria appear to be at the center of the changes orchestrated by HIF1α, but whether their morphology and ultrastructure change in response to HIF1α activation is unclear.
Here we will present our data on the occurrence and the role of mitochondrial remodelling in hypoxia. Our results indicate that remodelling of mitochondrial morphology and unltrastructure participate in the hypoxic adaptation.
Labels: MiParea: mt-Awareness
1-Dept Biol, Univ Padova, Italy. - [email protected]
2-IRCCS Fondazione Santa Lucia, Rome, Italy
3-Dulbecco-Telethon Inst, Venetian Inst Mol Med, Padova, Italy