Woodlief 2015 Obesity (Silver Spring): Difference between revisions
No edit summary |
No edit summary ย |
||
(4 intermediate revisions by 2 users not shown) | |||
Line 1: | Line 1: | ||
{{Publication | {{Publication | ||
|title=Woodlief TL, Carnero EA, Standley RA, Distefano G, Anthony SJ, Dubis GS, Jakicic JM, Houmard JA, Coen PM, Goodpaster BH (2015) Dose response of exercise training following roux-en-Y gastric bypass surgery: A randomized trial. | |title=Woodlief TL, Carnero EA, Standley RA, Distefano G, Anthony SJ, Dubis GS, Jakicic JM, Houmard JA, Coen PM, Goodpaster BH (2015) Dose response of exercise training following roux-en-Y gastric bypass surgery: A randomized trial. Obesity (Silver Spring) 23:2454-61. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/26537198 PMID: 26537198] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/26537198 PMID: 26537198] | ||
|authors=Woodlief TL, Carnero EA, Standley RA, Distefano G, Anthony SJ, Dubis GS, Jakicic JM, Houmard JA, Coen PM, Goodpaster BH | |authors=Woodlief TL, Carnero EA, Standley RA, Distefano G, Anthony SJ, Dubis GS, Jakicic JM, Houmard JA, Coen PM, Goodpaster BH | ||
|year=2015 | |year=2015 | ||
|journal= | |journal=Obesity (Silver Spring) | ||
|abstract=Roux-en-Y gastric bypass (RYGB) surgery can cause profound weight loss and improve overall cardiometabolic risk factors. Exercise (EX) training following RYGB can provide additional improvements in insulin sensitivity (S<sub>I</sub>) and cardiorespiratory fitness. However, it remains unknown whether a specific amount of EX post-RYGB is required to achieve additional benefits. | |abstract=Roux-en-Y gastric bypass (RYGB) surgery can cause profound weight loss and improve overall cardiometabolic risk factors. Exercise (EX) training following RYGB can provide additional improvements in insulin sensitivity (S<sub>I</sub>) and cardiorespiratory fitness. However, it remains unknown whether a specific amount of EX post-RYGB is required to achieve additional benefits. | ||
Line 15: | Line 15: | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area=Respiration, Exercise physiology;nutrition;life style, Patients | |area=Respiration, Exercise physiology;nutrition;life style, mt-Medicine, Patients | ||
|diseases=Diabetes, Obesity | |||
|organism=Human | |organism=Human | ||
|tissues=Skeletal muscle | |tissues=Skeletal muscle | ||
|preparations=Permeabilized tissue | |preparations=Permeabilized tissue | ||
|couplingstates=LEAK, OXPHOS, ET | |||
|couplingstates=LEAK, OXPHOS, | |pathways=N, NS | ||
| | |||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
}} | }} |
Latest revision as of 16:33, 13 November 2017
Woodlief TL, Carnero EA, Standley RA, Distefano G, Anthony SJ, Dubis GS, Jakicic JM, Houmard JA, Coen PM, Goodpaster BH (2015) Dose response of exercise training following roux-en-Y gastric bypass surgery: A randomized trial. Obesity (Silver Spring) 23:2454-61. |
Woodlief TL, Carnero EA, Standley RA, Distefano G, Anthony SJ, Dubis GS, Jakicic JM, Houmard JA, Coen PM, Goodpaster BH (2015) Obesity (Silver Spring)
Abstract: Roux-en-Y gastric bypass (RYGB) surgery can cause profound weight loss and improve overall cardiometabolic risk factors. Exercise (EX) training following RYGB can provide additional improvements in insulin sensitivity (SI) and cardiorespiratory fitness. However, it remains unknown whether a specific amount of EX post-RYGB is required to achieve additional benefits.
We performed a post hoc analysis of participants who were randomized into either a 6-month structured EX program or a health education control (CON). The EX group (nโ=โ56) was divided into tertiles according to the amount of weekly exercise performed, compared with CON (nโ=โ42): low-EXโ=โ54โยฑโ8; middle-EXโ=โ129โยฑโ4; and high-EXโ=โ286โยฑโ40 min per week.
The high-EX lost a significantly greater amount of body weight, total fat mass, and abdominal deep subcutaneous abdominal fat compared with CON (Pโ<โ0.005). SI improved to a greater extent in both the middle-EX and high-EX compared with CON (Pโ<โ0.04). Physical fitness (VO2 max) significantly improved in the high-EX (9.3%โยฑโ4.2%) compared with CON (-6.0โยฑโ2.4%) (Pโ<โ0.001). Skeletal muscle mitochondrial State 4 (Pโ<โ0.002) and 3 (Pโ<โ0.04) respiration was significantly higher in the high-EX compared with CON.
A modest volume of structured exercise provides additional improvements in insulin sensitivity following RYGB, but higher volumes of exercise are required to induce additional weight loss, changes in body composition, and improvements in cardiorespiratory fitness and skeletal muscle mitochondrial capacity.
โข O2k-Network Lab: US FL Orlando Goodpaster BH, US NC Greenville Neufer PD, US PA Pittsburgh Goodpaster BH
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style, mt-Medicine, Patients
Pathology: Diabetes, Obesity
Organism: Human Tissue;cell: Skeletal muscle Preparation: Permeabilized tissue
Coupling state: LEAK, OXPHOS, ET
Pathway: N, NS
HRR: Oxygraph-2k