Difference between revisions of "Wikstroem 1977 Nature"
Harrison DK (talk | contribs) (Created page with "{{Publication |title=Wikstroem MKF (1977) Proton pump coupled to cytochrome c oxidase in mitochondria. Nature 266: 271-273. |info=[http://www.ncbi.nlm.nih.gov/pubmed/15223 PMID:...") |
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{{Publication | {{Publication | ||
|title=Wikstroem MKF (1977) Proton pump coupled to cytochrome c oxidase in mitochondria. Nature 266: 271-273. | |title=Wikstroem MKF (1977) Proton pump coupled to cytochrome c oxidase in mitochondria. Nature 266: 271-273. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/15223 PMID: 15223] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/15223 PMID: 15223] | ||
|authors=Wikstroem MKF | |authors=Wikstroem MKF | ||
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|journal=Nature | |journal=Nature | ||
|abstract=Cytochrome c oxidase is an important enzyme of aerobic metabolism, catalysing electron transport between cytochrome c and molecular oxygen. Apart from this essential redox reaction the enzyme must be involved in conservation of the released redox energy for utilisation in ATP synthesis at the socalled third site of oxidative phosphorylation. I report here that the redox activity of mitochondrial cytochrome c oxidase is coupled to the translocation of hydrogen ions across the inner mitochondrial membrane. This finding may be a clue to the role of cytochrome oxidase in energy conservation. | |abstract=Cytochrome c oxidase is an important enzyme of aerobic metabolism, catalysing electron transport between cytochrome c and molecular oxygen. Apart from this essential redox reaction the enzyme must be involved in conservation of the released redox energy for utilisation in ATP synthesis at the socalled third site of oxidative phosphorylation. I report here that the redox activity of mitochondrial cytochrome c oxidase is coupled to the translocation of hydrogen ions across the inner mitochondrial membrane. This finding may be a clue to the role of cytochrome oxidase in energy conservation. | ||
|keywords= | |keywords=Cytochrome c oxidase, proton pump, inner mitochondrial membrane | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|enzymes=Complex IV; Cytochrome c Oxidase | |enzymes=Complex IV; Cytochrome c Oxidase | ||
|kinetics=Reduced Substrate; Cytochrome c | |kinetics=Reduced Substrate; Cytochrome c | ||
|topics=Ion Homeostasis | |topics=Respiration; OXPHOS; ETS Capacity, Coupling; Membrane Potential, Ion Homeostasis | ||
|additional=Made history | |additional=Made history | ||
}} | }} | ||
Revision as of 21:32, 22 June 2012
| Wikstroem MKF (1977) Proton pump coupled to cytochrome c oxidase in mitochondria. Nature 266: 271-273. |
Wikstroem MKF (1977) Nature
Abstract: Cytochrome c oxidase is an important enzyme of aerobic metabolism, catalysing electron transport between cytochrome c and molecular oxygen. Apart from this essential redox reaction the enzyme must be involved in conservation of the released redox energy for utilisation in ATP synthesis at the socalled third site of oxidative phosphorylation. I report here that the redox activity of mitochondrial cytochrome c oxidase is coupled to the translocation of hydrogen ions across the inner mitochondrial membrane. This finding may be a clue to the role of cytochrome oxidase in energy conservation. • Keywords: Cytochrome c oxidase, proton pump, inner mitochondrial membrane
Labels:
Enzyme: Complex IV; Cytochrome c Oxidase"Complex IV; Cytochrome c Oxidase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property. Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Coupling; Membrane Potential"Coupling; Membrane Potential" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Ion Homeostasis"Ion Homeostasis" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
Made history
