Ryu 2014 Cell Metab
| Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J (2014) A SIRT7-dependent acetylation switch of GABPΞ²1 controls mitochondrial function. Cell Metab 20:856-69. |
Ryu D, Jo YS, Lo Sasso G, Stein S, Zhang H, Perino A, Lee JU, Zeviani M, Romand R, Hottiger MO, Schoonjans K, Auwerx J (2014) Cell Metab
Abstract: Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is reflected by increased blood lactate levels, reduced exercise performance, cardiac dysfunction, hepatic microvesicular steatosis, and age-related hearing loss. This link between SIRT7 and mitochondrial function is translatable in humans, where SIRT7 overexpression rescues the mitochondrial functional defect in fibroblasts with a mutation in NDUFSI. These wide-ranging effects of SIRT7 on mitochondrial homeostasis are the consequence of the deacetylation of distinct lysine residues located in the hetero- and homodimerization domains of GABPΞ²1, a master regulator of nuclear-encoded mitochondrial genes. SIRT7-mediated deacetylation of GABPΞ²1 facilitates complex formation with GABPΞ± and the transcriptional activation of the GABPΞ±/GABPΞ² heterotetramer. Altogether, these data suggest that SIRT7 is a dynamic nuclear regulator of mitochondrial function through its impact on GABPΞ²1 function.
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Labels: MiParea: Respiration, mtDNA;mt-genetics, nDNA;cell genetics
Tissue;cell: Heart, Liver, Lung;gill
Coupling state: OXPHOS
HRR: Oxygraph-2k
Labels, 2016-09
