Hagl 2014 J Alzheimers Dis b: Difference between revisions
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Revision as of 17:44, 26 November 2014
| Hagl S, Heinrich M, Kocher A, Schiborr C, FrankcJ, Eckert GP (2014) Curcumin Micelles Improve Mitochondrial Function in a Mouse Model of Alzheimerβs Disease. The Journal of Prevention of Alzheimerβs Disease 1:80-83. |
Hagl S, Heinrich M, Kocher A, Schiborr C, FrankcJ, Eckert GP (2014) The Journal of Prevention of Alzheimerβs Disease
Abstract: Preventive strategies for late-onset Alzheimerβs disease (AD) should start early at a prodromal stage. Mitochondrial dysfunction has been found to play an important role in the initiation of both aging and the pathogenesis of Alzheimerβs disease. Curcumin, a widely used spice and food-coloring agent, is a polyphenol derived from the rhizome of Curcuma longa. It is known to have anti-oxidant, anti-inflammatory, and anti-protein-aggregate activities which are usually considered beneficial for mitochondrial function. We assessed brain mitochondrial function and concentrations of soluble AΞ²40 in a mouse model of AD (Thy1-APP751SL transgenic mice) after 3- week administration of curcumin micelles. Curcumin micelles are a newly developed formulation that account for increased curcumin bioavailability. Curcumin treatment had positive effects on mitochondrial membrane potential and respiratory control ratio. Additionally, it decreased levels of soluble AΞ²40 in brains of Thy1-APPSL transgenic mice. Hence, curcumin micelles are a promising neutraceutical for the prevention of AD. β’ Keywords: Curcumin, bioavailability, mitochondria, prevention, Alzheimer
β’ O2k-Network Lab: DE Frankfurt Eckert GP
Labels: MiParea: Respiration, Patients
Pathology: Alzheimer's
Organism: Mouse Tissue;cell: Nervous system Preparation: Isolated Mitochondria"Isolated Mitochondria" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property.
Coupling state: LEAK, OXPHOS, ETS"ETS" is not in the list (LEAK, ROUTINE, OXPHOS, ET) of allowed values for the "Coupling states" property.
HRR: Oxygraph-2k
Labels
