Agudelo 2014 Cell: Difference between revisions
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{{Publication | {{Publication | ||
|title=Agudelo LZ, FemenΓa T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DM, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL (2014) Skeletal muscle PGC-1Ξ±1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell 159:33-45. Β | |title=Agudelo LZ, FemenΓa T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DM, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL (2014) Skeletal muscle PGC-1Ξ±1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell 159:33-45. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/25259918 PMID:25259918] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/25259918 PMID:25259918] | ||
|authors=Agudelo LZ, Femenia T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DM, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL | |authors=Agudelo LZ, Femenia T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DM, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL | ||
|year=2014 | |year=2014 | ||
|journal=Cell | |journal=Cell | ||
|abstract=Depression is a debilitating condition with a profound impact on quality of life for millions of people worldwide. Physical exercise is used as a treatment strategy for many patients, but the mechanisms that underlie its beneficial effects remain unknown. Here, we describe a mechanism by which skeletal muscle PGC-1Ξ±1 induced by exercise training changes kynurenine metabolism and protects from stress-induced depression. Activation of the PGC-1Ξ±1-PPARΞ±/Ξ΄ pathway increases skeletal muscle expression of kynurenine aminotransferases, thus enhancing the conversion of kynurenine into kynurenic acid, a metabolite unable to cross the blood-brain barrier. Reducing plasma kynurenine protects the brain from stress-induced changes associated with depression and renders skeletal muscle-specific PGC-1Ξ±1 transgenic mice resistant to depression induced by chronic mild stress or direct kynurenine administration. This study opens therapeutic avenues for the treatment of depression by targeting the PGC-1Ξ±1-PPAR axis in skeletal muscle, without the need to cross the blood-brain barrier. Β | |abstract=Depression is a debilitating condition with a profound impact on quality of life for millions of people worldwide. Physical exercise is used as a treatment strategy for many patients, but the mechanisms that underlie its beneficial effects remain unknown. Here, we describe a mechanism by which skeletal muscle PGC-1Ξ±1 induced by exercise training changes kynurenine metabolism and protects from stress-induced depression. Activation of the PGC-1Ξ±1-PPARΞ±/Ξ΄ pathway increases skeletal muscle expression of kynurenine aminotransferases, thus enhancing the conversion of kynurenine into kynurenic acid, a metabolite unable to cross the blood-brain barrier. Reducing plasma kynurenine protects the brain from stress-induced changes associated with depression and renders skeletal muscle-specific PGC-1Ξ±1 transgenic mice resistant to depression induced by chronic mild stress or direct kynurenine administration. This study opens therapeutic avenues for the treatment of depression by targeting the PGC-1Ξ±1-PPAR axis in skeletal muscle, without the need to cross the blood-brain barrier. | ||
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|model cell lines=Other cell lines | |model cell lines=Other cell lines | ||
|diseases=Other | |diseases=Other | ||
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Revision as of 09:29, 25 March 2016
| Agudelo LZ, FemenΓa T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DM, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL (2014) Skeletal muscle PGC-1Ξ±1 modulates kynurenine metabolism and mediates resilience to stress-induced depression. Cell 159:33-45. |
Agudelo LZ, Femenia T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DM, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL (2014) Cell
Abstract: Depression is a debilitating condition with a profound impact on quality of life for millions of people worldwide. Physical exercise is used as a treatment strategy for many patients, but the mechanisms that underlie its beneficial effects remain unknown. Here, we describe a mechanism by which skeletal muscle PGC-1Ξ±1 induced by exercise training changes kynurenine metabolism and protects from stress-induced depression. Activation of the PGC-1Ξ±1-PPARΞ±/Ξ΄ pathway increases skeletal muscle expression of kynurenine aminotransferases, thus enhancing the conversion of kynurenine into kynurenic acid, a metabolite unable to cross the blood-brain barrier. Reducing plasma kynurenine protects the brain from stress-induced changes associated with depression and renders skeletal muscle-specific PGC-1Ξ±1 transgenic mice resistant to depression induced by chronic mild stress or direct kynurenine administration. This study opens therapeutic avenues for the treatment of depression by targeting the PGC-1Ξ±1-PPAR axis in skeletal muscle, without the need to cross the blood-brain barrier.
Labels: MiParea: Exercise physiology;nutrition;life style
Pathology: Other
Organism: Mouse Tissue;cell: Skeletal muscle
