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 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Abdurrachim 2014 Biochim Biophys Acta2014Abdurrachim D, Ciapaite J, Wessels B, Nabben M, Luiken JJ, Nicolay K, Prompers JJ (2014) Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo. Biochim Biophys Acta 1842:1525-37.LEAK
OXPHOS
ET
F
N
Isolated mitochondriaMouseHeart
Abdurrachim 2017 Cardiovasc Res2017Abdurrachim D, Nabben M, Hoerr V, Kuhlmann MT, Bovenkamp P, Ciapaite J, Geraets IME, Coumans W, Luiken JJFP, Glatz JFC, Schäfers M, Nicolay K, Faber C, Hermann S, Prompers JJ (2017) Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. Cardiovasc Res 113:1148-60.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseHeart
Abegg 2024 Toxicol Lett2024Abegg VF, Panajatovic MV, Mancuso RV, Allard JA, Duthaler U, Odermatt A, Krähenbühl S, Bouitbir J (2024) Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells. https://doi.org/10.1016/j.toxlet.2024.01.008LEAK
ROUTINE
OXPHOS
ET
N
S
DQ
CIV
ROX
Permeabilized cells
Intact cells
HumanLiver
Acin-Perez 2021 Life (Basel)2021Acin-Perez R, Benincá C, Shabane B, Shirihai OS, Stiles L (2021) Utilization of human samples for assessment of mitochondrial bioenergetics: gold standards, limitations, and future perspectives. Life (Basel) 11:949. doi: 10.3390/life11090949LEAK
ROUTINE
OXPHOS
ET
Intact organ
Permeabilized cells
Permeabilized tissue
Intact cells
HumanSkeletal muscle
Blood cells
Fibroblast
Platelet
Adant 2022 Mol Metab2022Adant I, Bird M, Decru B, Windmolders P, Wallays M, de Witte P, Rymen D, Witters P, Vermeersch P, Cassiman D, Ghesquière B (2022) Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction. https://doi.org/10.1016/j.molmet.2022.101537LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHumanFibroblast
Adeyemi 2019 Ecotoxicol Environ Saf2019Adeyemi JA, Machado ART, Ogunjimi AT, Alberici LC, Antunes LMG, Barbosa F Jr (2019) Cytotoxicity, mutagenicity, oxidative stress and mitochondrial impairment in human hepatoma (HepG2) cells exposed to copper oxide, copper-iron oxide and carbon nanoparticles. Ecotoxicol Environ Saf 189:109982.LEAK
ROUTINE
ET
Intact cellsHumanLiver
Afshordel 2014 Prostaglandins Leukot Essent Fatty Acids2014Afshordel S, Hagl S, Werner D, Roehner N, Koegel D, Bazan NG, Eckert GP (2014) Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging - impact of Bcl-2 and NPD-1 like metabolites. Prostaglandins Leukot Essent Fatty Acids 92:23-31.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMouseNervous system
Aguilaniu 2001 J Biol Chem2001Aguilaniu H, Gustafsson L, Rigoulet M, Nyström T (2001) Protein oxidation in G0 cells of Saccharomyces cerevisiae depends on the state rather than rate of respiration and is enhanced in pos9 but not yap1 mutants. J Biol Chem 276:35396-404.OXPHOS
ET
Saccharomyces cerevisiae
Fungi
Aguirre 2010 Biochim Biophys Acta2010Aguirre E, Rodríguez-Juárez F, Bellelli A, Gnaiger E, Cadenas S (2010) Kinetic model of the inhibition of respiration by endogenous nitric oxide in intact cells. Biochim Biophys Acta 1797:557-65. https://doi.org/10.1016/j.bbabio.2010.01.033LEAK
ROUTINE
ET
ROXIntact cells
Enzyme
Oxidase;biochemical oxidation
HEK
Ahmed 2019 Mol Nutr Food Res2019Ahmed N, Tcheng M, Roma A, Buraczynski M, Jayanth P, Rea K, Akhtar TA, Spagnuolo PA (2019) Avocatin B protects against lipotoxicity and improves insulin sensitivity in diet-induced obesity. Mol Nutr Food Res 63:e1900688.LEAK
ROUTINE
ET
N
ROX
Intact cellsMouse
Rat
Skeletal muscle
Islet cell;pancreas;thymus
Ahting 2009 Biochim Biophys Acta2009Ahting U, Floss T, Uez N, Schneider-Lohmar I, Becker L, Kling E, Iuso A, Bender A, de Angelis MH, Gailus-Durner V, Fuchs H, Meitinger T, Wurst W, Prokisch H, Klopstock T (2009) Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import. Biochim Biophys Acta 1787:371-76.OXPHOS
ET
N
S
Permeabilized cellsMouseStem cells
Aidt 2013 PLoS Curr2013Aidt FH, Nielsen SM, Kanters J, Pesta D, Nielsen TT, Nørremølle A, Hasholt L, Christiansen M, Hagen CM (2013) Dysfunctional mitochondrial respiration in the striatum of the Huntington's disease transgenic R6/2 mouse model. PLoS Curr 5. pii:ecurrents.hd.d8917b4862929772c5a2f2a34ef1c201.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateMouseNervous system
Airik 2023 Antioxidants (Basel)2023Airik M, Arbore H, Childs E, Huynh AB, Phua YL, Chen CW, Aird K, Bharathi S, Zhang B, Conlon P, Kmoch S, Kidd K, Bleyer AJ, Vockley J, Goetzman E, Wipf P, Airik R (2023) Mitochondrial ROS triggers KIN pathogenesis in FAN1-deficient kidneys. https://doi.org/10.3390/antiox12040900OXPHOS
ET
LEAK
N
S
NS
Isolated mitochondriaHumanKidney
Ajime 2020 Nicotine Tob Res2020Ajime TT, Serré J, Wüst RCI, Messa GAM, Poffé C, Swaminathan A, Maes K, Janssens W, Troosters T, Degens H, Gayan-Ramirez G (2020) Two weeks smoking cessation reverses cigarette smoke-induced skeletal muscle atrophy and mitochondrial dysfunction in mice. Nicotine Tob Res 23:143-51.LEAK
ET
SPermeabilized tissueMouseSkeletal muscle
Akinbiyi 2021 Sci Rep2021Akinbiyi EO, Abramowitz LK, Bauer BL, Stoll MSK, Hoppel CL, Hsiao CP, Hanover JA, Mears JA (2021) Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Sci Rep 11:22106.LEAK
OXPHOS
ET
F
N
S
DQ
CIV
NS
ROX
Permeabilized cells
Akude 2011 Diabetes2011Akude E, Zherebitskaya E, Chowdhury SK, Smith DR, Dobrowsky RT, Fernyhough P (2011) Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats. Diabetes 60:288-97.LEAK
OXPHOS
ET
N
CIV
Isolated mitochondriaRatNervous system
Al-Azab 2020 FEBS J2020Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X (2020) TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation. FEBS J 287:3088-104.LEAK
ROUTINE
OXPHOS
ET
N
ROX
Permeabilized cells
Intact cells
HumanOther cell lines
Al-Sabri 2024 Sci Rep2024Al-Sabri MH, Ammar N, Korzh S, Alsehli AM, Hosseini K, Fredriksson R, Mwinyi J, Williams MJ, Boukhatmi H, Schiöth HB (2024) Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes. https://doi.org/10.1038/s41598-024-53446-wLEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized tissueDrosophilaSkeletal muscle
Alahmad 2020 EMBO Mol Med2020Alahmad A, Nasca A, Heidler J, Thompson K, Oláhová M, Legati A, Lamantea E, Meisterknecht J, Spagnolo M, He L, Alameer S, Hakami F, Almehdar A, Ardissone A, Alston CL, McFarland R, Wittig I, Ghezzi D, Taylor RW (2020) Bi-allelic pathogenic variants in NDUFC2 cause early-onset Leigh syndrome and stalled biogenesis of complex I. EMBO Mol Med 12:e12619.LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Alan 2017 MiP2017
Alan Lukas

Role of MLQ protein in the structure and function of mammalian F1FO ATP-synthase.

ETHumanKidney
Alandijany 2013 J Neurovirol2013Alandijany T, Kammouni W, Roy Chowdhury SK, Fernyhough P, Jackson AC (2013) Mitochondrial dysfunction in rabies virus infection of neurons. J Neurovirol 19:537-49.LEAK
OXPHOS
ET
N
CIV
ROX
Permeabilized cellsRatNervous system
Alberici 2014 Abstract MiP2014Effects of long-chain acyl-CoA synthetase 6 knockdown in primary skeletal muscle cells metabolism.LEAK
ROUTINE
ET
Intact cellsRatSkeletal muscle
Albertini 2012 Abstract BioblastAlbertini E, Koziel R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
ET
Intact cellsEndothelial;epithelial;mesothelial cell
HUVEC
Albertini 2012 Aging (Albany NY)2012Albertini E, Kozieł R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Aging (Albany NY) 4:664-73.LEAK
ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
HUVEC
Alexander 2022 Cardiovasc Drugs Ther2022Alexander ED, Aldridge JL, Burleson TS, Frasier CR (2022) Teriflunomide treatment exacerbates cardiac ischemia reperfusion injury in isolated rat hearts. https://doi.org/10.1007/s10557-022-07341-zET
LEAK
OXPHOS
N
NS
Isolated mitochondriaRatHeart
Ali 2015 Abstract MiP2015Mitochondrial function and ROS homeostasis in young mouse heart and brain: the sex factor!LEAK
OXPHOS
ET
HomogenateMouseHeart
Nervous system
Ali 2015 Abstract MiPschool Cape Town 2015Early gender-related dimorphism in heart and brain mitochondria function and ROS dynamics.LEAK
OXPHOS
ET
MouseHeart
Nervous system
Allen 2020 Commun Biol2020Allen ME, Pennington ER, Perry JB, Dadoo S, Makrecka-Kuka M, Dambrova M, Moukdar F, Patel HD, Han X, Kidd GK, Benson EK, Raisch TB, Poelzing S, Brown DA, Shaikh SR (2020) The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats. Commun Biol 3:389.LEAK
OXPHOS
ET
N
S
CIV
Permeabilized tissueRatHeart
Allen 2020 Thesis2020Allen FM (2020) Mitochondrial metabolism elucidated by rapid fractionation from tissue. PhD Thesis 298.LEAK
ET
SIsolated mitochondriaMouse
Rat
Heart
Liver
Almoiliqy 2020 Acta Pharmacol Sin2020Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y (2020) Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin 41:1208-22.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
RatEndothelial;epithelial;mesothelial cell
Alston 2018 Am J Hum Genet2018Alston CL, Heidler J, Dibley MG, Kremer LS, Taylor LS, Fratter C, French CE, Glasgow RIC, Feichtinger RG, Delon I, Pagnamenta AT, Dolling H, Lemonde H, Aiton N, Bjørnstad A, Henneke L, Gärtner J, Thiele H, Tauchmannova K, Quaghebeur G, Houstek J, Sperl W, Raymond FL, Prokisch H, Mayr JA, McFarland R, Poulton J, Ryan MT, Wittig I, Henneke M, Taylor RW (2018) Bi-allelic mutations in NDUFA6 establish its role in early-onset isolated mitochondrial complex I deficiency. Am J Hum Genet 103:592-601.LEAK
ET
Intact cellsHumanFibroblast
Alston 2020 Am J Hum Genet2020Alston CL, Veling MT, Heidler J, Taylor LS, Alaimo JT, Sung AY, He L, Hopton S, Broomfield A, Pavaine J, Diaz J, Leon E, Wolf P, McFarland R, Prokisch H, Wortmann SB, Bonnen PE, Wittig I, Pagliarini DJ, Taylor RW (2020) Pathogenic bi-allelic mutations in NDUFAF8 cause Leigh syndrome with an isolated complex I deficiency. Am J Hum Genet 106:92-101.LEAK
ROUTINE
OXPHOS
ET
N
NS
Permeabilized cells
Intact cells
HumanFibroblast
Alvarez 2019 Chem Biol Interact2019Álvarez Santos MR, Duarte YB, Güiza FM, Romero Bohórquez AR, Mendez-Sanchez SC (2019) Effects of new tetrahydroquinoline-isoxazole hybrides on bioenergetics of hepatocarcinoma Hep-G2 cells and rat liver mitochondria. Chem Biol Interact 302:164-71.LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
Alves 2021 Eur J Nutr2021Alves BL, Araújo TDR, Guimarães DSPSF, Zoppi CC, Figueiredo MS, Carneiro EM (2021) Amino acid restriction alters survival mechanisms in pancreatic beta cells: possible role of the PI3K/Akt pathway. Eur J Nutr 60:3947-57.LEAK
ROUTINE
ET
ROXIntact cellsRatIslet cell;pancreas;thymus
Amaral 2016 Biochim Biophys Acta2016Amaral AU, Cecatto C, da Silva JC, Wajner A, Godoy KD, Ribeiro RT, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver: Possible implications for the pathogenesis of MCAD deficiency. Biochim Biophys Acta 1857:1363-72.LEAK
OXPHOS
ET
NIsolated mitochondriaRatNervous system
Liver
Amaral 2016 J Neurochem2016Amaral AU, Cecatto C, Castilho RF, Wajner M (2016) 2-methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria. J Neurochem 137:62-75.LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaRatNervous system
Ambrosio 2014 Free Radic Biol Med2014Ambrosio F, Brown E, Stolz D, Ferrari R, Goodpaster BH, Deasy B, Distefano G, Roperti A, Cheikhi A, Garciafigueroa Y, Barchowsky A (2014) Arsenic induces sustained impairment of skeletal muscle and muscle progenitor cell ultrastructure and bioenergetics. Free Radic Biol Med 74C:64-73.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Amigo 2016 Aging Cell2016Amigo I, Menezes-Filho SL, Luévano-Martínez LA, Chausse B, Kowaltowski AJ (2016) Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. Aging Cell 16:73-81.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseNervous system
Amoedo 2010 Abstract MiP2010Amoêdo ND, Rodrigues MF, Pezutto P, Lourenço MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: Studies on mitochondrial physiology and bioenergetics. Mitochondr Physiol Network 15.06.OXPHOS
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Amoedo 2011 PLoS One2011Amoedo ND, Rodrigues MF, Pezzuto P, Galina A, da Costa RM, de Almeida FC, El-Bacha T, Rumjanek FD (2011) Energy metabolism in h460 lung cancer cells: effects of histone deacetylase inhibitors. PLoS One 6:e22264.OXPHOS
ET
Intact cellsHumanLung;gill
Amoedo 2012 Abstract BioblastAmoedo ND, Rodrigues MF, Pereira SAS, Melo FH, Jasiulionis MG, Galina A, Rumjanek FD (2012) Mitochondrial function and bioenergetics during malignant transformation and metastasis. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
OXPHOS
ET
SIntact cellsMouseOther cell lines
Amoedo 2013 Abstract MiP2013Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Permeabilized cells
Enzyme
Intact cells
MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Anand 2016 PLOS ONE2016Anand R, Strecker V, Urbach J, Wittig I, Reichert AS (2016) Mic13 is essential for formation of crista junctions in mammalian cells. PLOS ONE 11:e0160258.LEAK
ROUTINE
OXPHOS
ET
N
CIV
NS
Other combinations
ROX
Permeabilized cells
Intact cells
HEK
Anand 2020 Toxicol In Vitro2020Anand CR, Bhavya B, Jayakumar K, Harikrishnan VS, Gopala S (2020) Inorganic nitrite alters mitochondrial dynamics without overt changes in cell death and mitochondrial respiration in cardiomyoblasts under hyperglycemia. Toxicol In Vitro 70:105048.LEAK
ROUTINE
ET
ROXIntact cellsRatHeart
Anderson 2009 J Am Coll Cardiol2009Anderson EJ, Kypson AP, Rodriguez E, Anderson CA, Lehr EJ, Neufer PD (2009) Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart. J Am Coll Cardiol 54:1891-8.OXPHOS
ET
Permeabilized tissueHumanHeart
Anderson 2009 J Clin Invest2009Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin C-T, Price JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD (2009) Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest 119:573-81.OXPHOS
ET
Permeabilized tissueHuman
Mouse
Rat
Skeletal muscle
Anderson 2011 Am J Physiol Heart Circ Physiol2011Anderson EJ, Rodriguez E, Anderson CA, Thayne K, Chitwood WR, Kypson AP (2011) Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways. Am J Physiol Heart Circ Physiol 300:H118-24.OXPHOS
ET
Permeabilized tissueHumanHeart
Anmann 2005 FEBS J2005Anmann T, Eimre M, Kuznetsov AV, Andrienko T, Kaambre T, Sikk P, Seppet E, Tiivel T, Vendelin M, Seppet EK, Saks VA (2005) Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS J 272:3145-61.OXPHOS
ET
Permeabilized cells
Permeabilized tissue
RatHeart
Antico 2021 Sci Adv2021Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK (2021) Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Sci Adv 7:eabj0722.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Intact cellsMouseNervous system
Anton 2019 Front Physiol2019Anton L, DeVine A, Polyak E, Olarerin-George A, Brown AG, Falk MJ, Elovitz MA (2019) HIF-1α stabilization increases miR-210 eliciting first trimester extravillous trophoblast mitochondrial dysfunction. Front Physiol 10:699.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanGenital
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