UK Leicester Martins LM

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UK Leicester Martins LM

OROBOROS O2k-Network

O2k-Network Lab Cell Death Regulation Laboratory, Room 302

MRC Toxicology Unit

Address Lancaster Road, LE1 9HN
City Leicester
Country United Kingdom
Contact Martins Miguel L
Team Celardo I, Eira da Costa Ana Carina, Lehmann S, Loh S
Team previous Ali Zubeya, Moisoi Nicoleta, Tufi R
Status O2k 2006-
OROBOROS Events MiP2013, IOC59
Topics Stress, Parkinson's Disease, Apoptosis, Mitochondrial Signalling


Published Reference
Tufi 2014 Nat Cell Biol 2014 Tufi R, Gandhi S, de Castro IP, Lehmann S, Angelova PR, Dinsdale D, Deas E, Plun-Favreau H, Nicotera P, Abramov AY, Willis AE, Mallucci GR, Loh SH, Martins LM (2014) Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat Cell Biol 16:157-66.
Macchi 2013 J Cell Sci 2013 Macchi M, El Fissi N, Tufi R, Bentobji M, LiƩvens JC, Martins LM, Royet J, Rival T (2013) The Drosophila inner-membrane protein PMI controls crista biogenesis and mitochondrial diameter. J Cell Sci 126:814-24.
De Castro IP 2013 Cell Death Dis 2013 de Castro IP, Costa AC, Celardo I, Tufi R, Dinsdale D, Loh SH, Martins LM (2013) Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants. Cell Death Dis 24:e873.
Pimenta 2012 Cell Death Differ 2012 Pimenta de Castro I, Costa AC, Lam D, Tufi R, Fedele V, Moisoi N, Dinsdale D, Deas E, Loh SH, Martins LM (2012) Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster. Cell Death Differ doi:10.1038/cdd.2012.5.
Moisoi 2009 Cell Death Differ 2009 Moisoi N, Klupsch K, Fedele V, East P, Sharma S, Renton A, Plun-Favreau H, Edwards RE, Teismann P, Esposti MD, Morrison AD, Wood NW, Downward J, Martins LM (2009) Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response. Cell Death Differ 16:449-64.


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