Krumschnabel G

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Krumschnabel G

COST Action CA15203 Mitochondrial fitness mapping
MITOEAGLE: Evolution - Age - Gender - Lifestyle - Environment


MitoPedia topics: EAGLE 

COST: Participant COST WG1: WG1 COST WG2: WG2 COST WG3: WG3 COST WG4: WG4


Name Krumschnabel Gerhard, Univ.Doz. Dr. Mag.
Institution
Gerhard Krumschnabel

OROBOROS INSTRUMENTS

O2k high-resolution respirometry

Address Schöpfstr. 18, 6020
City Innsbruck
State/Province
Country Austria
Email Gerhard.Krumschnabel@oroboros.at
Weblink www.oroboros.at www.bioblast.at
O2k-Network Lab AT Innsbruck OROBOROS


Labels: Field of research: Basic 



Publications

Published Reference
Krumschnabel 2015 Methods Mol Biol 2015
O2k-Protocols contents
Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E (2015) Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol 1264:245-61.
Makrecka-Kuka 2015 Biomolecules 2015
O2k-Protocols contents
Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. Biomolecules 5:1319-38.
Bock 2015 Sci Rep 2015 Bock FJ, Tanzer MC, Haschka MD, Krumschnabel G, Sohm B, Goetsch K, Kofler R, Villunger A (2015) The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death. Sci Rep 5:11268. doi: 10.1038/srep11268.
Krumschnabel 2014 Methods Enzymol 2014
O2k-Protocols contents
Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol 542:163-81.
Bock 2013 Cell Death Differ 2013 Bock FJ, Krumschnabel G, Manzl C, Peintner L, Tanzer MC, Hermann-Kleiter N, Baier G, Llacuna L, Yelamos J, Villunger A (2013) Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage. Cell Death Differ 20:546-57.
Manzl 2013 Cell Death Dis 2013 Manzl C, Fava LL, Krumschnabel G, Peintner L, Tanzer MC, Soratroi C, Bock FJ, Schuler F, Luef B, Geley S, Villunger A (2013) Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome. Cell Death Dis 4:e942.
Tischner 2012 Apoptosis 2012 Tischner D, Manzl C, Soratroi C, Villunger A, Krumschnabel G (2012) Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members. Apoptosis 17: 1197-1209.
Manzl 2012 Cell Death Differ 2012 Manzl C, Peintner L, Krumschnabel G, Bock F, Labi V, Drach M, Newbold A, Johnstone R, Villunger A (2012) PIDDosome-independent tumor suppression by Caspase-2. Cell Death Differ 19:1722-32.
Chara 2011 J Exp Zool A Ecol Genet Physiol 2011 Chara O, Espelt MV, Krumschnabel G, Schwarzbaum PJ (2011) Regulatory volume decrease and P receptor signaling in fish cells: mechanisms, physiology, and modeling approaches. J Exp Zool A Ecol Genet Physiol 315: 175-202.
Schwarzbaum 2011 Comp Biochem Physiol A Mol Integr Physio 2011 Schwarzbaum PJ, Krumschnabel G (2011) Perspective--from describing to understanding environment-physiology relations: 50th birthday of a branch in ecophysiology. Comp Biochem Physiol A Mol Integr Physio 158: 9-11.
Pafundo 2010 J Biol Chem 2010 Pafundo DE, Alvarez CL, Krumschnabel G, Schwarzbaum PJ (2010) A volume regulatory response can be triggered by nucleosides in human erythrocytes, a perfect osmometer no longer. J Biol Chem 285:6134-44.
Labi 2010 Genes Dev 2010 Labi V, Erlacher M, Krumschnabel G, Manzl C, Tzankov A, Pinon J, Egle A, Villunger A (2010) Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation. Genes Dev 24:1602-07.
Krumschnabel 2010 Aquat Toxicol 2010 Krumschnabel G, Ebner HL, Hess MW, Villunger A (2010) Apoptosis and necroptosis are induced in rainbow trout cell lines exposed to cadmium. Aquat Toxicol 99:73-85.
Podrabsky 2010 Apoptosis 2010 Podrabsky JE, Krumschnabel G (2010) Cell death beyond worms, flies and humans: Unusual model systems for cell death research. Apoptosis 15:243-8.
Grespi 2010 Cell Death Differ 2010 Grespi F, Soratroi C, Krumschnabel G, Sohm B, Ploner C, Geley S, Hengst L, Häcker G, Villunger A (2010) BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis. Cell Death Differ 17:1672-83.
Van Breukelen 2010 Apoptosis 2010 Van Breukelen F, Krumschnabel G, Podrabsky JE (2010) Vertebrate cell death in energy-limited conditions and how to avoid it: what we might learn from mammalian hibernators and other stress-tolerant vertebrates. Apoptosis 15:386-99.
Krumschnabel 2009 Oncogene 2009 Krumschnabel G, Manzl C, Villunger A (2009) Caspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspase. Oncogene 28:3093-6.
Manzl 2009 J Cell Biol 2009 Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, Logette E, Tschopp J, Villunger A (2009) Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol 185:291-303.
Krumschnabel 2009 Apoptosis 2009 Krumschnabel G, Podrabsky JE (2009) Fish as model systems for the study of vertebrate apoptosis. Apoptosis 14: 1-21.
Krumschnabel 2009 Cell Death Differ 2009 Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A (2009) The enigma of caspase-2: the laymen's view. Cell Death Differ 16:195-207.
Pafundo 2008 Am J Physiol 2008 Pafundo DE, Chara O, Faillace MP, Krumschnabel G, Schwarzbaum PJ (2008) Kinetics of ATP release and cell volume regulation of hyposmotically challenged goldfish hepatocytes. Am J Physiol 294: R220-R233.
Espelt 2008 Comp Biochem Physiol B Biochem Mol Biol 2008 Espelt MV, Alleva K, Amodeo G, Krumschnabel G, Rossi RC, Schwarzbaum PJ (2008) Volumetric response of vertebrate hepatocytes challenged by osmotic gradients: a theoretical approach. Comp Biochem Physiol B Biochem Mol Biol 150: 103-111.
Ebner 2007 J Exp Biol 2007 Ebner HL, Blatzer M, Nawaz M, Krumschnabel G (2007) Activation and nuclear translocation of ERK in response to ligand-dependent and -independent stimuli in liver and gill cells from rainbow trout. J Exp Biol 210: 1036-1045.
Krumschnabel 2007 Apoptosis 2007 Krumschnabel G, Maehr T, Nawaz M, Schwarzbaum PJ, Manzl C (2007) Staurosporine-induced cell death in salmonid cells: the role of apoptotic volume decrease, ion fluxes and MAP kinase signaling. Apoptosis 12: 1755-1768.
Ahmed 2006 J Exp Biol 2006 Ahmed KH, Pelster B, Krumschnabel G (2006) Signalling pathways involved in hypertonicity- and acidification-induced activation of Na+/H+ exchange in trout hepatocytes. J Exp Biol 209: 3101-3113.
Nawaz 2006 Toxicol Sci 2006 Nawaz M, Manzl C, Lacher V, Krumschnabel G (2006) Copper-induced stimulation of extracellular signal-regulated kinase in trout hepatocytes: the role of reactive oxygen species, Ca2+, and cell energetics and the impact of extracellular signal-regulated kinase signaling on apoptosis and necrosis. Toxicol Sci 92: 464-475.
Ebner 2006 Biochim Biophys Acta 2006 Ebner HL, Fiechtner B, Pelster B, Krumschnabel G (2006) Extracellular signal regulated MAP-kinase signalling in osmotically stressed trout hepatocytes. Biochim Biophys Acta 1760: 941-950.
Krumschnabel 2005 Toxicol Appl Pharmacol 2005 Krumschnabel G, Manzl C, Berger C, Hofer B (2005) Oxidative stress, mitochondrial permeability transition, and cell death in Cu-exposed trout hepatocytes. Toxicol Appl Pharmacol 209:62-73.
Ebner 2005 Am J Physiol 2005 Ebner HL, Cordas A, Pafundo DE, Schwarzbaum PJ, Pelster B, Krumschnabel G (2005) Importance of cytoskeletal elements in volume regulatory responses of trout hepatocytes. Am J Physiol 289: R877-R890.
Manzl 2004 J Exp Zool A 2004 Manzl C, Krumschnabel G, Schwarzbaum PJ, Chabicovsky M, Dallinger R (2004) Intracellular pH regulation in isolated hepatopancreas cells from the Roman snail (Helix pomatia). J Exp Zool A 301:75-84.
Manzl 2004 Comp Biochem Physiol C Toxicol Pharmacol 2004 Manzl C, Krumschnabel G, Schwarzbaum PJ, Dallinger R (2004) Acute toxicity of cadmium and copper in hepatopancreas cells from the Roman snail (Helix pomatia). Comp Biochem Physiol C Toxicol Pharmacol 138:45-52.
Krumschnabel 2004 Aquat Toxicol 2004 Krumschnabel G, Nawaz M (2004) Acute toxicity of hexavalent chromium in isolated teleost hepatocytes. Aquat Toxicol 70:159-167.
Pafundo 2004 Am J Physiol 2004 Pafundo DE, Mut P, Pérez Recalde M, González-Lebrero RM, Fachino V, Krumschnabel G, Schwarzbaum PJ (2004) Effects of extracellular nucleotides and their hydrolysis products on regulatory volume decrease of trout hepatocytes. Am J Physiol 287: R833-R843.
Rissanen 2003 Aquat Toxicol 2003 Rissanen E, Krumschnabel G, Nikinmaa M (2003) Dehydroabietic acid, a major component of wood industry effluents, interferes with cellular energetics in rainbow trout hepatocytes. Aquat Toxicol 62:45-53.
Krumschnabel 2003 J Exp Biol 2003 Krumschnabel G, Gstir R, Manzl C, Prem C, Pafundo D, Schwarzbaum PJ (2003) Metabolic and ionic responses of trout hepatocytes to anisosmotic exposure. J Exp Biol 206:1799-1808.
Manzl 2003 Toxicol Appl Pharmacol 2003 Manzl C, Ebner H, Köck G, Dallinger R, Krumschnabel G (2003) Copper, but not cadmium, is acutely toxic for trout hepatocytes: short-term effects on energetics and ion homeostasis. Toxicol Appl Pharmacol 191:235-244.
Alleva 2002 Comp Biochem Physiol B Biochem Mol Biol 2002 Alleva KE, Espelt MV, Krumschnabel G, Schwarzbaum PJ (2002) Identification of two distinct E-NTPDases in liver of goldfish (Carassius auratus L.). Comp Biochem Physiol B Biochem Mol Biol 131: 725-731..
Manzl 2002 J Exp Zool 2002 Manzl C, Schubert M, Schwarzbaum PJ, Krumschnabel G (2002) Effects of chemical anoxia on adrenergic responses of goldfish hepatocytes and the contribution of alpha- and beta-adrenoceptors. J Exp Zool 292: 468-476..
Krumschnabel 2001 Gen Comp Endocrinol 2001 Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Metabolic responses to epinephrine stimulation in goldfish hepatocytes: evidence for the presence of alpha-adrenoceptors. Gen Comp Endocrinol 121:205-213.
Wieser 2001 Biochem J 2001 Wieser W, Krumschnabel G (2001) Hierarchies of ATP-consuming processes: direct compared with indirect measurements, and comparative aspects. Biochem J 355:389-395.
Krumschnabel 2001 Physiol Biochem Zool 2001 Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Importance of glycolysis for the energetics of anoxia-tolerant and anoxia-intolerant teleost hepatocytes. Physiol Biochem Zool 74:413-419.
Krumschnabel 2001 J Exp Biol 2001 Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Regulation of intracellular pH in anoxia-tolerant and anoxia-intolerant teleost hepatocytes. J Exp Biol 204:3943-3951.
Krumschnabel 2000b J Exp Biol 2000b Krumschnabel G, Biasi C, Wieser W (2000b) Action of adenosine on energetics, protein synthesis and K(+) homeostasis in teleost hepatocytes. J Exp Biol 203:2657-2665.
Krumschnabel 2000a J Exp Biol 2000a Krumschnabel G, Schwarzbaum PJ, Lisch J, Biasi C, Wieser W (2000a) Oxygen-dependent energetics of anoxia-tolerant and anoxia-intolerant hepatocytes. J Exp Biol 203:951-959.
Krumschnabel 1999 Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1999 Krumschnabel G, Schwarzbaum PJ, Wieser W (1999) Energetics of trout hepatocytes during A23187-induced disruption of Ca2+ homeostasis. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 124:187-195.
Krumschnabel 1998 Arch Biochem Biophys 1998 Krumschnabel G, Frischmann ME, Schwarzbaum PJ, Wieser W (1998) Loss of K+ homeostasis in trout hepatocytes during chemical anoxia: a screening study for potential causes and mechanisms. Arch Biochem Biophys 353: 199-206.
Schwarzbaum 1998 Am J Physiol 1998 Schwarzbaum PJ, Frischmann ME, Krumschnabel G, Rossi RC, Wieser W (1998) Functional role of ecto-ATPase activity in goldfish hepatocytes. Am J Physiol 274: R1031-R1038.
Krumschnabel 1997 Am J Physiol 1997 Krumschnabel G, Schwarzbaum PJ, Biasi C, Dorigatti M, Wieser W (1997) Effects of energy limitation on Ca2+ and K+ homeostasis in anoxia-tolerant and anoxia-intolerant hepatocytes. Am J Physiol 273:R307-316.
Krumschnabel 1997 J Comp Physiol B 1997 Krumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1997) Acute and chronic effects of temperature, and of nutritional state, on ion homeostasis and energy metabolism in teleost hepatocytes. J Comp Physiol B 167:280-6.
Krumschnabel 1996 Am J Physiol 1996 Krumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1996) Membrane-metabolic coupling and ion homeostasis in anoxia-tolerant and anoxia-intolerant hepatocytes. Am J Physiol 270:R614-620.
Schwarzbaum 1996 J Exp Biol 1996 Schwarzbaum P, Bernabeu R, Krumschnabel G, Wieser C (1996) Effect of chemical anoxia on protein kinase C and Na+, K+-ATPase in hepatocytes of goldfish (Carassius auratus) and rainbow trout (Oncorhynchus mykiss). J Exp Biol 199: 1515-1521.
Krumschnabel 1994 J Exp Biol 1994 Krumschnabel G, Malle S, Schwarzbaum PJ, Wieser W (1994) Glycolytic function in goldfish hepatocytes at different temperatures: relevance for Na+ pump activity and protein synthesis. J Exp Biol 193:285-90.
Krumschnabel 1994 Physiol Zool 1994 Krumschnabel G, Schwarzbaum PJ, Wieser W (1994) Coupling of energy supply and energy demand in isolated goldfish hepatocytes. Physiol Zool 67:438-448.
Krumschnabel 1994 Experientia 1994 Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-485.


Abstracts

Published Reference
Krumschnabel 2016b Abstract MitoFit Science Camp 2016 2016 O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.
Doerrier 2016 Abstract MitoFit Science Camp 2016 2016 Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.
Sumbalova 2016b Abstract MitoFit Science Camp 2016 2016 Human blood cells: isolation and HRR.
Gnaiger 2016 Abstract EBEC Riva del Garda 2016 2016 MitoFit and MITOEAGLE – towards a global data bank on mitochondrial physiology.
Krumschnabel 2016a Abstract MitoFit Science Camp 2016 2016 O2k-Protocols: Mitochondrial preparations for HRR.
Lamberti 2016 Abstract MitoFit Science Camp 2016 2016 Development of a reference sample for HRR.
Sumbalova 2016a Abstract MitoFit Science Camp 2016 2016 Optimizing strategies on the malate concentration in SUIT protocols.
Gnaiger 2015 Abstract MiP2015 2015 Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.
Krumschnabel 2014 Abstract MiP2014 2014 Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.
Sumbalova 2014 Abstract MiP2014 2014 Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain.
Krumschnabel 2013 Abstract MiP2013 2013 Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.
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