Krumschnabel G

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Evolution-Age-Gender-Lifestyle-Environment  » COST Action CA15203 Mitochondrial fitness mapping

Krumschnabel G


MitoPedia topics: EAGLE 

COST: Member COST WG1: WG1 COST WG2: WG2 COST WG3: WG3 COST WG4: WG4


Name Krumschnabel Gerhard, Univ.Doz. Dr. Mag.
Institution
Gerhard Krumschnabel

OROBOROS INSTRUMENTS

O2k high-resolution respirometry

Address Schöpfstr. 18, 6020
City Innsbruck
State/Province
Country Austria
Email Gerhard.Krumschnabel@oroboros.at
Weblink www.oroboros.at www.bioblast.at
O2k-Network Lab AT Innsbruck OROBOROS


Labels: Field of research: Basic 



Publications

 PublishedReference
Krumschnabel 2015 Methods Mol Biol2015
O2k-Protocols contents
Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E (2015) Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol 1264:245-61.
Makrecka-Kuka 2015 Biomolecules2015
O2k-Protocols contents
Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. Biomolecules 5:1319-38.
Bock 2015 Sci Rep2015Bock FJ, Tanzer MC, Haschka MD, Krumschnabel G, Sohm B, Goetsch K, Kofler R, Villunger A (2015) The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death. Sci Rep 5:11268. doi: 10.1038/srep11268.
Krumschnabel 2014 Methods Enzymol2014
O2k-Protocols contents
Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol 542:163-81.
Bock 2013 Cell Death Differ2013Bock FJ, Krumschnabel G, Manzl C, Peintner L, Tanzer MC, Hermann-Kleiter N, Baier G, Llacuna L, Yelamos J, Villunger A (2013) Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage. Cell Death Differ 20:546-57.
Manzl 2013 Cell Death Dis2013Manzl C, Fava LL, Krumschnabel G, Peintner L, Tanzer MC, Soratroi C, Bock FJ, Schuler F, Luef B, Geley S, Villunger A (2013) Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome. Cell Death Dis 4:e942.
Tischner 2012 Apoptosis2012Tischner D, Manzl C, Soratroi C, Villunger A, Krumschnabel G (2012) Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members. Apoptosis 17: 1197-1209.
Manzl 2012 Cell Death Differ2012Manzl C, Peintner L, Krumschnabel G, Bock F, Labi V, Drach M, Newbold A, Johnstone R, Villunger A (2012) PIDDosome-independent tumor suppression by Caspase-2. Cell Death Differ 19:1722-32.
Chara 2011 J Exp Zool A Ecol Genet Physiol2011Chara O, Espelt MV, Krumschnabel G, Schwarzbaum PJ (2011) Regulatory volume decrease and P receptor signaling in fish cells: mechanisms, physiology, and modeling approaches. J Exp Zool A Ecol Genet Physiol 315: 175-202.
Schwarzbaum 2011 Comp Biochem Physiol A Mol Integr Physio2011Schwarzbaum PJ, Krumschnabel G (2011) Perspective--from describing to understanding environment-physiology relations: 50th birthday of a branch in ecophysiology. Comp Biochem Physiol A Mol Integr Physio 158: 9-11.
Podrabsky 2010 Apoptosis2010Podrabsky JE, Krumschnabel G (2010) Cell death beyond worms, flies and humans: Unusual model systems for cell death research. Apoptosis 15:243-8.
Grespi 2010 Cell Death Differ2010Grespi F, Soratroi C, Krumschnabel G, Sohm B, Ploner C, Geley S, Hengst L, Häcker G, Villunger A (2010) BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis. Cell Death Differ 17:1672-83.
Van Breukelen 2010 Apoptosis2010Van Breukelen F, Krumschnabel G, Podrabsky JE (2010) Vertebrate cell death in energy-limited conditions and how to avoid it: what we might learn from mammalian hibernators and other stress-tolerant vertebrates. Apoptosis 15:386-99.
Labi 2010 Genes Dev2010Labi V, Erlacher M, Krumschnabel G, Manzl C, Tzankov A, Pinon J, Egle A, Villunger A (2010) Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation. Genes Dev 24:1602-07.
Pafundo 2010 J Biol Chem2010Pafundo DE, Alvarez CL, Krumschnabel G, Schwarzbaum PJ (2010) A volume regulatory response can be triggered by nucleosides in human erythrocytes, a perfect osmometer no longer. J Biol Chem 285:6134-44.
Krumschnabel 2010 Aquat Toxicol2010Krumschnabel G, Ebner HL, Hess MW, Villunger A (2010) Apoptosis and necroptosis are induced in rainbow trout cell lines exposed to cadmium. Aquat Toxicol 99:73-85.
Krumschnabel 2009 Apoptosis2009Krumschnabel G, Podrabsky JE (2009) Fish as model systems for the study of vertebrate apoptosis. Apoptosis 14: 1-21.
Krumschnabel 2009 Cell Death Differ2009Krumschnabel G, Sohm B, Bock F, Manzl C, Villunger A (2009) The enigma of caspase-2: the laymen's view. Cell Death Differ 16:195-207.
Krumschnabel 2009 Oncogene2009Krumschnabel G, Manzl C, Villunger A (2009) Caspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspase. Oncogene 28:3093-6.
Manzl 2009 J Cell Biol2009Manzl C, Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, Logette E, Tschopp J, Villunger A (2009) Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol 185:291-303.
Espelt 2008 Comp Biochem Physiol B Biochem Mol Biol2008Espelt MV, Alleva K, Amodeo G, Krumschnabel G, Rossi RC, Schwarzbaum PJ (2008) Volumetric response of vertebrate hepatocytes challenged by osmotic gradients: a theoretical approach. Comp Biochem Physiol B Biochem Mol Biol 150: 103-111.
Pafundo 2008 Am J Physiol2008Pafundo DE, Chara O, Faillace MP, Krumschnabel G, Schwarzbaum PJ (2008) Kinetics of ATP release and cell volume regulation of hyposmotically challenged goldfish hepatocytes. Am J Physiol 294: R220-R233.
Krumschnabel 2007 Apoptosis2007Krumschnabel G, Maehr T, Nawaz M, Schwarzbaum PJ, Manzl C (2007) Staurosporine-induced cell death in salmonid cells: the role of apoptotic volume decrease, ion fluxes and MAP kinase signaling. Apoptosis 12: 1755-1768.
Ebner 2007 J Exp Biol2007Ebner HL, Blatzer M, Nawaz M, Krumschnabel G (2007) Activation and nuclear translocation of ERK in response to ligand-dependent and -independent stimuli in liver and gill cells from rainbow trout. J Exp Biol 210: 1036-1045.
Nawaz 2006 Toxicol Sci2006Nawaz M, Manzl C, Lacher V, Krumschnabel G (2006) Copper-induced stimulation of extracellular signal-regulated kinase in trout hepatocytes: the role of reactive oxygen species, Ca2+, and cell energetics and the impact of extracellular signal-regulated kinase signaling on apoptosis and necrosis. Toxicol Sci 92: 464-475.
Ebner 2006 Biochim Biophys Acta2006Ebner HL, Fiechtner B, Pelster B, Krumschnabel G (2006) Extracellular signal regulated MAP-kinase signalling in osmotically stressed trout hepatocytes. Biochim Biophys Acta 1760: 941-950.
Ahmed 2006 J Exp Biol2006Ahmed KH, Pelster B, Krumschnabel G (2006) Signalling pathways involved in hypertonicity- and acidification-induced activation of Na+/H+ exchange in trout hepatocytes. J Exp Biol 209: 3101-3113.
Ebner 2005 Am J Physiol2005Ebner HL, Cordas A, Pafundo DE, Schwarzbaum PJ, Pelster B, Krumschnabel G (2005) Importance of cytoskeletal elements in volume regulatory responses of trout hepatocytes. Am J Physiol 289: R877-R890.
Krumschnabel 2005 Toxicol Appl Pharmacol2005Krumschnabel G, Manzl C, Berger C, Hofer B (2005) Oxidative stress, mitochondrial permeability transition, and cell death in Cu-exposed trout hepatocytes. Toxicol Appl Pharmacol 209:62-73.
Manzl 2004 J Exp Zool A2004Manzl C, Krumschnabel G, Schwarzbaum PJ, Chabicovsky M, Dallinger R (2004) Intracellular pH regulation in isolated hepatopancreas cells from the Roman snail (Helix pomatia). J Exp Zool A 301:75-84.
Manzl 2004 Comp Biochem Physiol C Toxicol Pharmacol2004Manzl C, Krumschnabel G, Schwarzbaum PJ, Dallinger R (2004) Acute toxicity of cadmium and copper in hepatopancreas cells from the Roman snail (Helix pomatia). Comp Biochem Physiol C Toxicol Pharmacol 138:45-52.
Krumschnabel 2004 Aquat Toxicol2004Krumschnabel G, Nawaz M (2004) Acute toxicity of hexavalent chromium in isolated teleost hepatocytes. Aquat Toxicol 70:159-167.
Pafundo 2004 Am J Physiol2004Pafundo DE, Mut P, Pérez Recalde M, González-Lebrero RM, Fachino V, Krumschnabel G, Schwarzbaum PJ (2004) Effects of extracellular nucleotides and their hydrolysis products on regulatory volume decrease of trout hepatocytes. Am J Physiol 287: R833-R843.
Manzl 2003 Toxicol Appl Pharmacol2003Manzl C, Ebner H, Köck G, Dallinger R, Krumschnabel G (2003) Copper, but not cadmium, is acutely toxic for trout hepatocytes: short-term effects on energetics and ion homeostasis. Toxicol Appl Pharmacol 191:235-244.
Rissanen 2003 Aquat Toxicol2003Rissanen E, Krumschnabel G, Nikinmaa M (2003) Dehydroabietic acid, a major component of wood industry effluents, interferes with cellular energetics in rainbow trout hepatocytes. Aquat Toxicol 62:45-53.
Krumschnabel 2003 J Exp Biol2003Krumschnabel G, Gstir R, Manzl C, Prem C, Pafundo D, Schwarzbaum PJ (2003) Metabolic and ionic responses of trout hepatocytes to anisosmotic exposure. J Exp Biol 206:1799-1808.
Alleva 2002 Comp Biochem Physiol B Biochem Mol Biol2002Alleva KE, Espelt MV, Krumschnabel G, Schwarzbaum PJ (2002) Identification of two distinct E-NTPDases in liver of goldfish (Carassius auratus L.). Comp Biochem Physiol B Biochem Mol Biol 131: 725-731..
Manzl 2002 J Exp Zool2002Manzl C, Schubert M, Schwarzbaum PJ, Krumschnabel G (2002) Effects of chemical anoxia on adrenergic responses of goldfish hepatocytes and the contribution of alpha- and beta-adrenoceptors. J Exp Zool 292: 468-476..
Wieser 2001 Biochem J2001Wieser W, Krumschnabel G (2001) Hierarchies of ATP-consuming processes: direct compared with indirect measurements, and comparative aspects. Biochem J 355:389-395.
Krumschnabel 2001 Physiol Biochem Zool2001Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Importance of glycolysis for the energetics of anoxia-tolerant and anoxia-intolerant teleost hepatocytes. Physiol Biochem Zool 74:413-419.
Krumschnabel 2001 J Exp Biol2001Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Regulation of intracellular pH in anoxia-tolerant and anoxia-intolerant teleost hepatocytes. J Exp Biol 204:3943-3951.
Krumschnabel 2001 Gen Comp Endocrinol2001Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Metabolic responses to epinephrine stimulation in goldfish hepatocytes: evidence for the presence of alpha-adrenoceptors. Gen Comp Endocrinol 121:205-213.
Krumschnabel 2000b J Exp Biol2000bKrumschnabel G, Biasi C, Wieser W (2000b) Action of adenosine on energetics, protein synthesis and K(+) homeostasis in teleost hepatocytes. J Exp Biol 203:2657-2665.
Krumschnabel 2000a J Exp Biol2000aKrumschnabel G, Schwarzbaum PJ, Lisch J, Biasi C, Wieser W (2000a) Oxygen-dependent energetics of anoxia-tolerant and anoxia-intolerant hepatocytes. J Exp Biol 203:951-959.
Krumschnabel 1999 Comp Biochem Physiol C Pharmacol Toxicol Endocrinol1999Krumschnabel G, Schwarzbaum PJ, Wieser W (1999) Energetics of trout hepatocytes during A23187-induced disruption of Ca2+ homeostasis. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 124:187-195.
Krumschnabel 1998 Arch Biochem Biophys1998Krumschnabel G, Frischmann ME, Schwarzbaum PJ, Wieser W (1998) Loss of K+ homeostasis in trout hepatocytes during chemical anoxia: a screening study for potential causes and mechanisms. Arch Biochem Biophys 353: 199-206.
Schwarzbaum 1998 Am J Physiol1998Schwarzbaum PJ, Frischmann ME, Krumschnabel G, Rossi RC, Wieser W (1998) Functional role of ecto-ATPase activity in goldfish hepatocytes. Am J Physiol 274: R1031-R1038.
Krumschnabel 1997 Am J Physiol1997Krumschnabel G, Schwarzbaum PJ, Biasi C, Dorigatti M, Wieser W (1997) Effects of energy limitation on Ca2+ and K+ homeostasis in anoxia-tolerant and anoxia-intolerant hepatocytes. Am J Physiol 273:R307-316.
Krumschnabel 1997 J Comp Physiol B1997Krumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1997) Acute and chronic effects of temperature, and of nutritional state, on ion homeostasis and energy metabolism in teleost hepatocytes. J Comp Physiol B 167:280-6.
Schwarzbaum 1996 J Exp Biol1996Schwarzbaum P, Bernabeu R, Krumschnabel G, Wieser C (1996) Effect of chemical anoxia on protein kinase C and Na+, K+-ATPase in hepatocytes of goldfish (Carassius auratus) and rainbow trout (Oncorhynchus mykiss). J Exp Biol 199: 1515-1521.
Krumschnabel 1996 Am J Physiol1996Krumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1996) Membrane-metabolic coupling and ion homeostasis in anoxia-tolerant and anoxia-intolerant hepatocytes. Am J Physiol 270:R614-620.
Krumschnabel 1994 Experientia1994Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-5.
Krumschnabel 1994 J Exp Biol1994Krumschnabel G, Malle S, Schwarzbaum PJ, Wieser W (1994) Glycolytic function in goldfish hepatocytes at different temperatures: relevance for Na+ pump activity and protein synthesis. J Exp Biol 193:285-90.
Krumschnabel 1994 Physiol Zool1994Krumschnabel G, Schwarzbaum PJ, Wieser W (1994) Coupling of energy supply and energy demand in isolated goldfish hepatocytes. Physiol Zool 67:438-448.

Abstracts

 PublishedReference
Sumbalova 2016a Abstract MitoFit Science Camp 20162016Optimizing strategies on the malate concentration in SUIT protocols.
Gnaiger 2016 Abstract EBEC Riva del Garda 20162016MitoFit and MITOEAGLE – towards a global data bank on mitochondrial physiology.
Sumbalova 2016b Abstract MitoFit Science Camp 20162016Human blood cells: isolation and HRR.
Krumschnabel 2016b Abstract MitoFit Science Camp 20162016O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck2016Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.
Lamberti 2016 Abstract MitoFit Science Camp 20162016Development of a reference sample for HRR.
Doerrier 2016a Abstract Mito Xmas Meeting Innsbruck2016
MitoFit
MitoFit and MITOEAGLE – towards a global data bank on mitochondrial physiology.
Krumschnabel 2016a Abstract MitoFit Science Camp 20162016O2k-Protocols: Mitochondrial preparations for HRR.
Krumschnabel 2016 Abstract Mito Xmas Meeting Innsbruck2016Establishment of a reference sample for high-resolution respirometry.
Doerrier 2016 Abstract MitoFit Science Camp 20162016Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.
Gnaiger 2015 Abstract MiP20152015Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.
Krumschnabel 2014 Abstract MiP20142014Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.
Sumbalova 2014 Abstract MiP20142014Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain.
Krumschnabel 2013 Abstract MiP20132013Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.