Koopman WJ

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Koopman WJ

COST Action CA15203 Mitochondrial fitness mapping
MITOEAGLE: Evolution - Age - Gender - Lifestyle - Environment


MitoPedia topics: EAGLE 

COST: Participant


COST WG4: WG4


Name Koopman Werner J H, PhD
Institution
Werner Koopman
MiPsociety

Dept. of Biochemistry (286)

Nijmegen Centre for Molecular Life Sciences

Radboud University Nijmegen Medical Centre

Address ,
City Nijmegen
State/Province
Country Netherlands
Email w.koopman@ncmls.ru.nl
Weblink Nijmegen Centre for Molecular Life Sciences
O2k-Network Lab NL Nijmegen Koopman WJ


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Publications

Published Reference
Koopman 2016 EMBO Mol Med 2016 Koopman WJ, Beyrath J, Fung CW, Koene S, Rodenburg RJ, Willems PH, Smeitink JA (2016) Mitochondrial disorders in children: toward development of small-molecule treatment strategies. EMBO Mol Med 8:311-27.
Iannetti 2016 Nat Protoc 2016 Iannetti EF, Smeitink JA, Beyrath J, Willems PH, Koopman WJ (2016) Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy. Nat Protoc 11:1693-710.
Willems 2015 Cell Metab 2015 Willems PH, Rossignol R, Dieteren CE, Murphy MP, Koopman WJ (2015) Redox homeostasis and mitochondrial dynamics. Cell Metab 22:207-18.
Schoeckel 2015 Cancer Metab 2015 Schöckel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, Algire C, Hägebarth A, Willems PH, Kopitz C, Koopman WJ, Héroult M (2015) Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth. Cancer Metab 3:11.
Grefte 2015 Biochim Biophys Acta 2015 Grefte S, Wagenaars JA, Jansen R, Willems PH, Koopman WJ (2015) Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2. Biochim Biophys Acta 1853:1606-14.
Liemburg-Apers 2015 Biophys J 2015 Liemburg-Apers DC, Schirris TJ, Russel FG, Willems PH, Koopman WJ (2015) Mitoenergetic dysfunction triggers a rapid compensatory increase in steady-state glucose flux. Biophys J 109:1372-86.
Schirris 2015 Cell Metab 2015 Schirris TJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BG, Brandt U, Koopman WJ, Beyrath JD, Rodenburg RJ, Willems PH, Smeitink JA, Russel FG (2015) Statin-induced myopathy is associated with mitochondrial complex III inhibition. Cell Metab 22:399-407.
Blanchet 2015 Sci Rep 2015 Blanchet L, Smeitink JA, van Emst-de Vries SE, Vogels C, Pellegrini M, Jonckheere AI, Rodenburg RJ, Buydens LM, Beyrath J, Willems PH, Koopman WJ (2015) Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning. Sci Rep 5:8035.
Forkink 2014 Biochim Biophys Acta 2014 Forkink M, Manjeri GR, Liemburg-Apers DC, Nibbeling E, Blanchard M, Wojtala A, Smeitink JA, Wieckowski MR, Willems PH, Koopman WJ (2014) Mitochondrial hyperpolarization during chronic Complex I inhibition is sustained by low activity of Complex II, III, IV and V. Biochim Biophys Acta 1837:1247-56.
Willems 2013 Antioxid Redox Signal 2013 Willems P, Wanschers BF, Esseling J, Szklarczyk R, Kudla U, Duarte I, Forkink M, Nooteboom M, Swarts H, Gloerich J, Nijtmans L, Koopman W, Huynen MA (2013) BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletion. Antioxid Redox Signal 18:129-38.
Distelmaier 2012 Antioxid Redox Signal 2012 Distelmaier F, Valsecchi F, Forkink M, van Emst-de Vries S, Swarts HG, Rodenburg RJ, Verwiel ET, Smeitink JA, Willems PH, Koopman WJ (2012) Trolox-sensitive reactive oxygen species regulate mitochondrial morphology, oxidative phosphorylation and cytosolic calcium handling in healthy cells. Antioxid Redox Signal 17:1657-69.
Koopman 2012 N Engl J Med 2012 Koopman WJ, Willems PH, Smeitink JA (2012) Monogenic mitochondrial disorders. N Engl J Med 366:1132-41.
Heeman 2011 J Cell Sci 2011 Heeman B, Van den Haute C, Aelvoet SA, Valsecchi F, Rodenburg RJ, Reumers V, Debyser Z, Callewaert G, Koopman WJ, Willems PH, Baekelandt V (2011) Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance. J Cell Sci 124:1115-25.
Dieteren 2011 Proc Natl Acad Sci U S A 2011 Dieteren CE, Gielen SC, Nijtmans LG, Smeitink JA, Swarts HG, Brock R, Willems PH, Koopman WJ (2011) Solute diffusion is hindered in the mitochondrial matrix. Proc Natl Acad Sci U S A 108:8657-62.
Koopman 2010 Antioxid Redox Signal 2010 Koopman WJ, Nijtmans LG, Dieteren CE, Roestenberg P, Valsecchi F, Smeitink JA, Willems PH (2010) Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation. Antioxid Redox Signal 12:1431-70.
Distelmaier 2009 Brain 2009 Distelmaier F, Koopman WJ, van den Heuvel LP, Rodenburg RJ, Mayatepek E, Willems PH, Smeitink JA (2009) Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease. Brain 132:833-42.
Eisenberg 2008 Hum Mol Genet 2008 Eisenberg I, Novershtern N, Itzhaki Z, Becker-Cohen M, Sadeh M, Willems PH, Friedman N, Koopman WJ, Mitrani-Rosenbaum S (2008) Mitochondrial processes are impaired in hereditary inclusion body myopathy. Hum Mol Genet 17:3663-74.
Mortiboys 2008 Ann Neurol 2008 Mortiboys H, Thomas KJ, Koopman WJ, Klaffke S, Abou-Sleiman P, Olpin S, Wood NW, Willems PH, Smeitink JA, Cookson MR, Bandmann O (2008) Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol 64:555-65.
Boxma 2005 Nature 2005 Boxma B, de Graaf RM, van der Staay GW, van Alen TA, Ricard G, Gabaldón T, van Hoek AH, Moon-van der Staay SY, Koopman WJ, van Hellemond JJ, Tielens AG, Friedrich T, Veenhuis M, Huynen MA, Hackstein JH (2005) An anaerobic mitochondrion that produces hydrogen. Nature 434:74-9..


Abstracts

Published Reference
Iannetti 2015 Abstract MiP2015 2015 High-Content Screening of mitochondrial morphofunction in living cells.
Koopman 2015 Abstract MiP2015 2015 Mitoenergetic dysfunction triggers a rapid compensatory increase in steady-state glucose flux.
Wagenaars 2014 Abstract IOC 2014-04 Schroecken 2014 Wagenaars J, Willems PHGM, Koopman WJ (2014) Oxygen consumption in OXPHOS-deficient cells. Mitochondr Physiol Network 19.02.
Koopman 2014 Abstract MiP2014 2014 Redox regulation of mitochondrial dynamics and function.
Grefte 2014 Abstract MiP2014 2014 Myotube formation does not require mitochondrial ATP production but is inhibited by rotenone via the Rho-associated, coiled-coil containing protein kinase II.
Wojtala 2014 Abstract MiP2014 2014 Proteomic analysis of mitochondrial Complex I deficient mouse model - impact of Complex I deficiency on p66Shc-Ser36 phosphorylation pathway in NDUFS4-/- mouse tissues.
Koopman 2013 Abstract MiP2013 2013 Koopman WJH (2013) Developing novel treatment strategies for mitochondrial disease. Mitochondr Physiol Network 18.08.
Koopman 2012 Abstract Bioblast 2012 Koopman WJ (2012) Cellular consequences of mitochondrial dysfunction. Mitochondr Physiol Network 17.12.
Tronstad 2012 Abstract Bioblast 2012 Nikolaisen J, Nilsson LIH, Hagland HR, Koopman WJ, Tronstad KJ (2012) Mitochondrial morphology and biogenesis in cellular stress. Mitochondr Physiol Network 17.12.


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