Houstek J

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Name Houstek Josef, Prof., MD PhD
Houstek J.jpg

Institute of Physiology

Academy of Sciences of the Czech Rep.

Address Videnska 1083, 14220
City Prague
Country Czech Republic
Email houstek@biomed.cas.cz
O2k-Network Lab CZ Prague Houstek J

Labels: Field of research: Basic, Clinical, Diagnostic 


Published Reference
Milerova 2016 Mol Cell Biochem 2016 Milerová M, Drahota Z, Chytilová A, Tauchmannová K, Houštěk J, Ošťádal B (2016) Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load. Mol Cell Biochem 412:147-54.
Hejzlarova 2015 Biochem J 2015 Hejzlarová K, Kaplanová V, Nůsková H, Kovářová N, Ješina P, Drahota Z, Mráček T, Seneca S, Houštěk J (2015) Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of Fo-a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation. Biochem J 466:601-11.
Pecina 2014 Biochim Biophys Acta Clinical 2014 Pecina P, Houstkova H, Mracek T, Pecinova A, Nuskova H.Tesarova M, Hansikova H, Janota J, Zemanc J, Houstek J (2014) Noninvasive diagnostics of mitochondrial disorders in isolated lymphocytes with high resolution respirometry. Biochim Biophys Acta Clinical 2:62–71.
Stiburek 2012 Mol Biol Cell 2012 Stiburek L, Cesnekova J, Kostkova O, Fornuskova D, Vinsova K, Wenchich L, Houstek J, Zeman J (2012) YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation. Mol Biol Cell 23: 1010-1023.
Benes 2011 Clin Sci (Lond) 2011 Benes J, Kazdova L, Drahota Z, Houstek J, Medrikova D, Kopecky J, Kovarova N, Vrbacky M, Sedmera D, Strnad H, Kolar M, Petrak J, Benada O, Skaroupkova P, Cervenka L, Melenovsky V (2011) Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats. Clin Sci (Lond) 121:29-41.
Pecinova 2011 Mitochondrion 2011 Pecinova A, Drahota Z, Nuskova H, Pecina P, Houstek J (2011) Evaluation of basic mitochondrial functions using rat tissue homogenates. Mitochondrion 11:722-8.
Havlickova 2010 Biochim Biophys Acta 2010 Havlíčková V, Kaplanová V, Nůsková H, Drahota Z, Houštěk J (2010) Knockdown of F1 epsilon subunit decreases mitochondrial content of ATP synthase 2 and leads to accumulation of subunit c. Biochim Biophys Acta 1797:1124-9.
Nuskova 2010 J Bioenerg Biomembr 2010 Nůsková H, Vrbacký M, Drahota Z, Houštěk J (2010) Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase. J Bioenerg Biomembr 42:395-403.
Kus 2008 Am J Physiol Endocrinol Metab 2008 Kus V, Prazak T, Brauner P, Hensler M, Kuda O, Flachs P, Janovska P, Medrikova D, Rossmeisl M, Jilkova Z, Stefl B, Pastalkova E, Drahota Z, Houstek J, Kopecky J (2008) Induction of muscle thermogenesis by high-fat diet in mice: Association with obesity-resistance. Am J Physiol Endocrinol Metab 295:356-67.
Hervouet 2008 Carcinogenesis 2008 Hervouet E, Cízková A, Demont J, Vojtísková A, Pecina P, Franssen-van Hal NL, Keijer J, Simonnet H, Ivánek R, Kmoch S, Godinot C, Houstek J (2008) HIF and reactive oxygen species regulate oxidative phosphorylation in cancer. Carcinogenesis 29:1528-37.
Cizkova 2008 Nat Genet 2008 Cızkova A, Stranecky V, Mayr JA, Tesarova M, Havlıckova V, Paul J, Ivanek R, Kuss AW, Hansıkova H, Kaplanova W, Vrbacky M, Hartmannova H, Noskova L, Honzık T, Drahota Z, Magner M, Hejzlarova K, Sperl W, Zeman J, Houstek J, Kmoch S (2008) TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy. Nat Genet 40:1288-90.
Vrbacky 2007 Biochim Biophys Acta 2007 Vrbacky M, Drahota Z, Mracek T, Vojtískova A, Jesina P, Stopka P, Houstek J (2007) Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria. Biochim Biophys Acta 1767:989-97.
Honzik 2006 Placenta 2006 Honzik T, Drahota Z, Bohm M, Jesina P, Mracek T, Paul J, Zeman J, Houstek J (2006) Specific properties of heavy fraction of mitochondria from human-term placenta - Glycerophosphate-dependent hydrogen peroxide production. Placenta 27:348-56.
Hervouet 2006 Biochem Biophys Res Commun 2006 Hervouet E, Pecina P, Demont J, Vojtíšková A, Simonnet H, Houštek J, Godinot C (2006) Inhibition of cytochrome c oxidase subunit 4 precursor processing by the hypoxia mimic cobalt chloride. Biochem Biophys Res Commun 344:1086-93.
Labajova 2006 Anal Biochem 2006 Labajova A, Vojtiskova A, Krivakova P, Kofranek J, Drahota Z, Houstek J (2006) Evaluation of mitochondrial membrane potential using a computerized device with a tetraphenylphosphonium-selective electrode. Anal Biochem 353:37-42.
Hervouet 2005 Carcinogenesis 2005 Hervouet E, Demont J, Pecina P, Vojtísková A, Houstek J, Simonnet H, Godinot C (2005) A new role for the von Hippel-Lindau tumor suppressor protein: Stimulation of mitochondrial oxidative phosphorylation complex biogenesis. Carcinogenesis 26:531-9.
Drahota 2005 Physiol Res 2005 Drahota Z, Krivakova P, Cervinkova Z, Kmonickova E, Lotkova H, Kucera O, Houstek J (2005) Tert-butyl hydroperoxide selectively inhibits mitochondrial respiratory-chain enzymes in isolated rat hepatocytes. Physiol Res 54:67-72.
Rauchova 2005 Biochem Biophys Res Comm 2005 Rauchova H, Vrbacky M, Bergamini C, Fato R, Lenaz G, Houstek J, Drahota Z (2005) Inhibition of glycerophosphate-dependent H2O2 generation in brown fat mitochondria by idebenone. Biochem Biophys Res Comm 339:362-6.
Drahota 2005 Cell Biochem Biophys 2005 Drahota Z, Milerova M, Stieglerova A, Skarka L, Houstek J, Ostadal B (2005) Development of cytochrome-c oxidase in rat heart. Cell Biochem Biophys 43:87-94.
Jesina 2004 Physiol Res 2004 Jesina P, Kholova D, Bolehovska R, Cervinkova Z, Drahota Z, Houstek J (2004) Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria. Physiol Res 53:305-10.
Pecina 2004 Physiol Res 2004 Pecina P, Houstkova H, Hansikova H, Zeman J, Houstek J (2004) Genetic defects of cytochrome c oxidase assembly. Physiol Res 53 Suppl 1:S213-23.
Mayr 2004 Pediatr Res 2004 Mayr JA, Paul J, Pecina P, Kurnik P, Forster H, Fotschl U, Sperl W, Houstek J (2004) Reduced respiratory control with ADP and changed pattern of respiratory chain enzymes as a result of selective deficiency of the mitochondrial ATP synthase. Pediatr Res 55:988-94.
Pecina 2004 Am J Physiol Cell Physiol 2004 Pecina P, Gnaiger E, Zeman J, Pronicka E, Houstek J (2004) Decreased affinity to oxygen of cytochrome c oxidase in Leigh syndrome caused by SURF1 mutations. Am J Physiol Cell Physiol 287:C1384-8.
Jesina 2004 Biochem J 2004 Jesina P, Tesarova M, Fornuskova D, Vojtiskova A, Pecina P, Kaplanova V, Hansikova H, Zeman J, Houstek J (2004) Diminished synthesis of subunit a (ATP6) and altered function of ATP synthase and cytochrome c oxidase due to the mtDNA 2 bp microdeletion of TA at positions 9205 and 9206. Biochem J 383:561-71.
Pecina 2003 Biochim Biophys Acta 2003 Pecina P, Capkova M, Roy Chowdhury SK, Drahota Z, Dubot A, Vojtiskova A, Hansikova H, Houstekova H, Zeman J, Godinot C, Houstek J (2003) Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome. Biochim Biophys Acta 1639:53-63.
Wenchich 2003 Physiol Res 2003 Wenchich L, Drahota Z, Honzík T, Hansíková H, Tesarová M, Zeman J, Houstek J (2003) Polarographic evaluation of mitochondrial enzymes activity in isolated mitochondria and in permeabilized human muscle cells with inherited mitochondrial defects. Physiol Res 52:781-88.
Drahota 2002 J Bioenerg Biomembr 2002 Drahota Z, Roy Chowdhury SK, Floryk D, Mrácek T, Wilhelm J, Rauchova H, Lenaz G, Houstek J (2002) Glycerophosphate-dependent hydrogen peroxide production by brown adipose tissue mitochondria and ist activation by ferricyanide. J Bioenerg Biomembr 34:105-13.
Roy Chowdhury 2000 Clin Chim Acta 2000 Roy Chowdhury SK, Drahota Z, Floryk D, Calda P, Houstek J (2000) Activities of mitochondrial oxidative phosphorylation enzymes in cultured amniocytes. Clin Chim Acta 298:157-73.


Published Reference
Karbanova 2015 Abstract MiP2015 2015 CD36 does not directly participate in mitochondrial fatty acid transport and oxidation.
Kovarova 2015 Abstract MiP2015 2015 Tissue- and species-specific differences in cytochrome c oxidase assembly induced by SURF1 defects.
Kaplanova 2015 Abstract MiP2015 2015 Functional ablation of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice.
Pecina 2015 Abstract MiP2015 2015 Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of L-asparaginase in childhood ALL cells.
Pecinova 2015 Abstract MiP2015 2015 Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue.
Tauchmannova 2015 Abstract MiP2015 2015 Assembly of subunit Fo-a into mammalian ATP synthase.
Nuskova 2015 Abstract MiPschool London 2015 2015 Insufficient energy provision or increased oxidative stress – what matters more in ATP synthase deficiencies?
Mracek 2015 Abstract MiP2015 2015 Myocardial iron and mitochondrial function in failing and non-failing human heart: direct tissue analysis.
Kovalcikova 2015 Abstract MiPschool London 2015 2015 TMEM70 ablation leads to embryonic lethality in mouse knockout due to impairment of ATP synthase.
Kovalcikova 2015 Abstract MiP2015 2015 Derangements of myocardial mitochondrial function in patients with end-stage heart failure is associated with reduced endonuclease G.
Houstek 2014 Abstract MiP2014 2014 Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of Fo-a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation.
Pecina 2014 Abstract MiP2014 2014 Manifestation of mitochondrial disorders of nuclear origin in lymphocytes.
Mracek 2014 Abstract MiP2014 2014 Function of mitochondrial energy provision apparatus is compromised in patients with chronic heart failure. Mitochondr Physiol Network 19.13.
Pecina 2013 Abstract MiP2013 2013 Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08.
Nuskova 2011 Abstract IOC61 2011 Nuskova H, Pecina P, Kovarova N, Dell’Agnello C, Zeviani M, Houstek J (2011) Cytochrome c oxidase with decreased H+/e− ratio in SURF1 knockout mice. MiPNet16.01.

Participated at

2012-09-16: Happy birthday to Dr. Josef Houstek - 65 active years - and many more!!
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