Gellerich FN

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Name Gellerich Frank Norbert, Priv. Doz., Dr.
Institution
Address FNG - Mitochondrienlabor der Neurologischen Universitätsklinik

Universitätsklinikum Magdeburg A.ö.R.

Leipziger Str. 44

D-39120 Magdeburg, Germany,

City
State/Province
Country
Email frank.gellerich@med.ovgu.de
Weblink
O2k-Network Lab AT Innsbruck OROBOROS, DE Magdeburg Gellerich FN


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Publications

Published Reference
Gainutdinov 2015 Arch Biochem Biophys 2015 Gainutdinov T, Molkentin JD, Siemen D, Ziemer M, Debska-Vielhaber G, Vielhaber S, Gizatullina Z, Orynbayeva Z, Gellerich FN (2015) Knockout of cyclophilin D in Ppif(-/-) mice increases stability of brain mitochondria against Ca(2+) stress. Arch Biochem Biophys 579:40-6.
Kupsch 2014 J Neural Transm 2014 Kupsch A, Schmidt W, Gizatullina Z, Debska-Vielhaber G, Voges J, Striggow F, Panther P, Schwegler H, Heinze HJ, Vielhaber S, Gellerich FN (2014) 6-Hydroxydopamine impairs mitochondrial function in the rat model of Parkinson's disease: respirometric, histological, and behavioral analyses. J Neural Transm 121:1245-57.
Trumbeckaite 2013 Mitochondrion 2013 Trumbeckaite S, Gizatullina Z, Arandarcikaite O, Röhnert P, Vielhaber S, Malesevic M, Fischer G, Seppet E, Striggow F, Gellerich FN (2013) Oxygen glucose deprivation causes mitochondrial dysfunction in cultivated rat hippocampal slices: Protective effects of CsA, its immunosuppressive congener [D-Ser](8)CsA, the novel non-immunosuppressive cyclosporin derivative Cs9, and the NMDA receptor antagonist MK 801. Mitochondrion 13:539–47.
Gellerich 2012 Biochem J 2012 Gellerich FN, Gizatullina Z, Trumbeckaite S, Korzeniewski B, Gaynutdinov T, Seppet E, Vielhaber S, Heinze HJ, Striggow F (2012) Cytosolic Ca2+ regulates the energisation of isolated brain mitochondria by formation of pyruvate through the malate-aspartate shuttle. Biochem J 443:747-55.
Thiede 2012 Biochim Biophys Acta 2012 Thiede A, Gellerich FN, Schönfeld P, Siemen D. (2012) Complex effects of 17β-estradiol on mitochondrial function. Biochim Biophys Acta 1817:1747-53.
Gizatullina 2011 Mitochondrion 2011 Gizatullina ZZ, Gaynutdinov TM, Svoboda H, Jerzembek D, Knabe A, Vielhaber S, Malesevic M, Heinze HJ, Fischer G, Striggow F, Gellerich FN (2011) Effects of cyclosporine A and its immunosuppressive or non-immunosuppressive derivatives [D-Ser]8-CsA and Cs9 on mitochondria from different brain regions. Mitochondrion 11(3):421-9.
Gellerich 2010 Biochim Biophys Acta 2010 Gellerich FN, Gizatullina Z, Trumbeckaite S, Nguyen HP, Pallas T, Arandarcikaite O, Vielhaber S, Seppet E, Striggow F (2010) The regulation of OXPHOS by extramitochondrial calcium. Biochim Biophys Acta 1797:1018-27.
Kadaja 2010 Exp Clin Cardiol 2010 Kadaja L, Eimre M, Paju K, Roosimaa M, Podramaegi T, Kaasik P, Pehme A, Orlova E, Mudist M, Peet N, Piirsoo A, Seene T, Gellerich FN, Seppet EK (2010) Impaired oxidative phosphorylation in overtrained rat myocardium. Exp Clin Cardiol 15:116-27.
Krebiehl 2010 PLoS One 2010 Krebiehl G, Ruckerbauer S, Burbulla LF, Kieper N, Maurer B, Waak J, Wolburg H, Gizatullina Z, Gellerich FN, Woitalla D, Riess O, Kahle PJ, Proikas-Cezanne T, Krueger R (2010) Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One 5:e9367.
Gellerich 2009 PLoS One 2009 Gellerich FN, Gizatullina Z, Arandarcikaite O, Jerzembek D, Vielhaber S, Seppet E, Striggow F (2009) Extramitochondrial Ca2+ in the nanomolar range regulates glutamate-dependent oxidative phosphorylation on demand. PloS One 4:e8181.
Kuznetsov 2008 Nat Protoc 2008 Kuznetsov AV, Veksler V, Gellerich FN, Saks V, Margreiter R, Kunz WS (2008) Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells. Nat Protoc 3:965-76.
Gellerich 2008 J Biol Chem 2008 Gellerich FN, Gizatullina Z, Nguyen HP, Trumbeckaite S, Vielhaber S, Seppet E, Zierz S, Landwehrmeyer B, Riess O, von Hörsten S, Striggow F (2008) Impaired regulation of brain mitochondria by extramitochondrial Ca2+ in transgenic huntington disease rats. J Biol Chem 283:30715-24.
Kuhnt 2007 Neurochem Res 2007 Kuhnt T, Pelz T, Qu X, Haensgen G, Dunst J, Gellerich FN (2007) Mitochondrial OXPHOS functions in R1H rhabdomyosarcoma and skeletal muscles of the rat. Neurochem Res 32:973–80.
Seppet 2005 Mol Cell Biochem 2005 Seppet E, Eimre M, Peet N, Paju K, Orlova E, Ress M, Kovask S, Piirsoo A, Saks VA, Gellerich FN, Zierz S, Seppet EK (2005) Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery. Mol Cell Biochem 270:49-61.
Werner 2005 Arch Tierz Dummerstorf 2005 Werner C, Opalka JR, Gellerich FN, Wicke M (2005) The influence of mitochondrial function on meat quality in turkey and swine. Arch Tierz Dummerstorf 48 Special Issue: 106-114.
Gizatullina 2005 Biochim Biophys Acta 2005 Gizatullina ZZ, Chen Y, Zierz S, Gellerich FN (2005) Effects of extramitochondrial ADP on permeability transition of mouse liver mitochondria. Biochim Biophys Acta 1706:98-104.
Opalka 2004 Br Poult Sci 2004 Opalka JR, Wicke M, Gellerich FN, Schmidt R, Rosner F, Zierz S, von Lengerken G (2004) Mitochondrial function in turkey skeletal muscle - impact on meat quality. Br Poult Sci 45:367-79.
Traufeller 2004 Biochim Biophys Acta 2004 Traufeller K, Gellerich FN, Zierz S (2004) Different sensitivities of CPT I and CPT II for inhibition by L-aminocarnitine in human skeletal muscle. Biochim Biophys Acta 1608:149-54.
Gellerich 2004 Mol Cell Biochem 2004 Gellerich FN, Trumbeckaite S, Müller T, Deschauer M, Chen Y, Gizatullina Z, Zierz S (2004) Energetic depression caused by mitochondrial dysfunction. Mol Cell Biochem 256/257:391-405.
Kuznetsov 2003 Anal Biochem 2003 Kuznetsov AV, Kunz WS, Saks V, Usson Y, Mazat J-P, Letellier T, Gellerich FN, Margreiter R (2003) Cryopreservation of mitochondria and mitochondrial function in cardiac and skeletal muscle fibers. Anal Biochem 319:296-303.
Seppet 2003 Cardiac Remodeling and Failure 2003 Seppet E, Peet N, Paju K, Ress M, Saks V, Gellerich FN, Chen Y, Trumbeckaite S, Prondzinsky R, Silber R, Werdan K, Zierz S, Seppet EK (2003) Mitochondrial function in failing human myocardium in vitro: atrioventricular differences. In: Cardiac Remodeling and Failure (Singal P, Dixon I, Lorrie A. Kirshenbaum L, Dhalla N eds. Kiuwer Academic Publishers, Boston: 459-470.
Gellerich 2002 Biochim Biophys Acta (Vol 1556) 2002 Gellerich FN, Deschauer M, Chen Y, Müller T, Neudecker S, Zierz S (2002) Mitochondrial respiratory rates and activities of respiratory chain complexes correlate linearly with heteroplasmy of deleted mtDNA without threshold and independently of deletion size. Biochim Biophys Acta 1556:41-52.
Gellerich 2002 Biochim Biophys Acta (Vol 1554) 2002 Gellerich FN, Laterveer FD, Zierz S, Nicolay K (2002) The quantitation of ADP diffusion gradients across the outer membrane of heart mitochondria in the presence of macromolecules. Biochim Biophys Acta 1554:48-56.
Opalka 2002 Biochem Pharmacol 2002 Opalka JR, Gellerich FN, Kling L, Müller-Beckmann B, Zierz S (2002) Effect of the new matrix metalloproteinase inhibitor RO-28-2653 on mitochondrial function. Biochem Pharmacol 63:725-32.
Trumbeckaite 2001 Eur J Biochem 2001 Trumbeckaite S, Opalka JR, Neuhof C, Zierz S, Gellerich FN (2001) Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function. Eur J Biochem 268:1422-9.
Braun 2001 Biochim Biophys Acta 2001 Braun U, Paju K, Eimre M, Seppet E, Orlova E, Kadaja L, Trumbeckaite S, Gellerich FN, Zierz S, Jockusch H, Seppet EK (2001) Lack of dystrophin is associated with altered integration of the mitochondria and ATPases in slow-twitch muscle cells of MDX mice. Biochim Biophys Acta 1505:258-70.
Sperl 1997 Mol Cell Biochem 1997 Sperl W, Skladal D, Gnaiger E, Wyss M, Mayr U, Hager J, Gellerich FN (1997) High resolution respirometry of premeabilized skeletal muscle fibers in the diagnosis of neuromuscular disorders. Mol Cell Biochem 174:71-8.
Laterveer 1996 FEBS Lett 1996 Laterveer FD, Nicolay K, Gellerich FN (1996) ADP delivery from adenylate kinase in the mitochondrial intermembrane space to oxidative phosphorylation increases in the presence of macromolecules. FEBS Lett 386:255-9.
Wisniewski 1995 Eur J Biochem 1995 Wisniewski E, Gellerich FN, Kunz WS (1995) Distribution of flux control among the enzymes of mitochondrial oxidative phosphorylation in calcium-activated saponin-skinned rat musculus soleus fibers. Eur J Biochem 230:549-54.
Laterveer 1995 Eur J Biochem 1995 Laterveer FD, Gellerich FN, Nicolay K (1995) Macromolecules increase the channelling of ADP from externally associated hexokinase to the matrix of mitochondria. Eur J Biochem 232:569-77.
Gellerich 1995 HRR 1995 Gellerich FN, Skladal D, Schranzhofer R, Lanznaster N, Kunz WS, Wisniewski E, Kuznetsov A, Krishmer M, Gnaiger E, Margreiter R, Sperl W (1995) Hochauflösende Respirometrie und multiple Substrat/Inhibitor-Titration zum funktionellen Nachweis mitochondrialer Defekte in permeabilisierten Muskelfasern. In: Molekulare Grundlage hereditärer Myopathien. (Gross M, Gresser U, Hrsg), Zuckschwerdt Verlag, München, Bern, Wien, New York:52-66.
Gellerich 1994 BTK-263 1994
BTK1994
Gellerich FN, Steinlechner R, Wyss M, Eberl T, Müller LC, Skladal D, Sperl W, Dapunt O, Margreiter R, Gnaiger E (1994) Mitochondrial function in the atrial appendage of the human heart. Characterization by high-resolution respirometry. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermo-Kinetics 3. Innsbruck Univ Press:263-7.
Kunz 1994 Anal Biochem 1994 Kunz WS, Kuznetsov AV, Winkler K, Gellerich FN, Neuhof S, Neumann HW (1994) Measurement of fluorescence changes of NAD(P)H and fluorescent flavoproteins in saponin-skinned fibers. Anal Biochem 216:322-7.
Gellerich 1994 BTK-181 1994
BTK1994
Gellerich FN, Laterveer FD, Gnaiger E, Nicolay K (1994) Effect of macromolecules on ADP-transport into mitochondria. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:181-5.
Laterveer 1994 BTK-186 1994
BTK1994
Laterveer FD, Gellerich FN, Gnaiger E, Nicolay K (1994) Macromolecules increase the channeling of ADP from mitochondrially associated hexokinase to the mitochondrial matrix. In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:186-90.
Gnaiger 1994 BTK 1994
BTK1994
Gnaiger E, Gellerich FN, Wyss M (1994) What is controlling life? 50 years after Erwin Schrödinger's What is life? Modern trends in BiothermoKinetics 3, Innsbruck Univ Press:336 pp.
Sperl 1994 J Inher Metab Dis 1994 Sperl W, Skladal D, Lanznaster N, Schranzhofer R, Zaunschirm G, Gnaiger E, Gellerich FN (1994) Polarographic studies of saponin-skinned muscle fibers in patients with mitochondrial myopathies. J Inher Metab Dis 17:307-10.
Knoblechner 1994 BTK-294 1994
BTK1994
Knoblechner A, Steinlechner R, Schirmer M, Gellerich FN, Margreiter R, Konwalinka G, Gnaiger E (1994) The effect of 2-chlorodeoxy-adenosine on endogenous respiration of a human lymphoma cell line (U-937). In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:294-6.
Skladal 1994 BTK-268 1994
BTK1994
Skladal D, Sperl W, Schranzhofer R, Krismer M, Gnaiger E, Margreiter R, Gellerich FN (1994) Preservation of mitochondrial functions in human skeletal muscle during storage in high energy preservation solution (HEPS). In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:268-71.
Kunz 1993 Biochim Biophys Acta 1993 Kunz WS, Kuznetsov AV, Schulze W, Eichhorn K, Schild L, Striggow F, Bohnensack R, Grasshoff H, Neumann HW, Gellerich FN (1993) Functional characterization of mitochondrial oxidative phosphorylation in saponin-skinned human muscle fibers. Biochim Biophys Acta 1144:46-53.
Kunz 1993 FEBS Lett 1993 Kunz WS, Kuznetsov AV, Gellerich FN (1993) Mitochondrial oxidative phosphorylation in saponin-skinned human muscle fibers is stimulated by caffeine. FEBS Lett 323:188-90.


Abstracts

Published Reference
Gellerich 2013 Abstract MiP2013 2013 Gellerich FN, Korzeniewski B, Gizatullina Z, Debska-Vielhaber G, Gainutdinov T, König R, Reymann K, Vielhaber S(2013) The mitochondrial gas pedal, a unique property of neurons exists also in heart and skeletal muscle but not in astrocytes. New evidences by in silico investigations and (patho-)physiological consequences. Mitochondr Physiol Network 18.08.

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