Fischer 2012 Abstract Bioblast
|Fischer M (2012) Myofacial pain syndrome and myofascial trigger points. Mitochondr Physiol Network 17.12.|
Fischer M (2012)
Event: Bioblast 2012
A recent study in the European Union found that musculoskeletal disorders account for 49% of all absences from work and 60% of permanent disability at an estimated cost of €240 billion . However, treatment of chronic musculoskeletal pain is limited in its efficacy in part because the neurobiological mechanisms responsible for pain have not been fully elucidated. Myofacial pain syndrome is characterized by the presence of myofascial trigger points (MTrPs), which are defined as hyperirritable nodules located within a taut band of skeletal muscle . While active MTrPs generate local and referred spontaneous pain, latent MTrPs can only elicit such pain when palpated; nevertheless, both types appear to be responsible for motor dysfunction associated with range of motion and stiffness issues. Recent cytokine findings in MTrPs in the context of ischemia and local pH changes suggest that mitochondria may be dysfunctional and play a key role in the pathogenesis . Looking at mitochondrial function in MTrPs may help to determine what pharmacological and/or other manual therapy strategies might be useful to treat myofascial pain. It will be important to identify key biochemical entities to target future research.
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• Myofacial pain syndrome, Myofascial trigger points MiPNetLab: AT Innsbruck Fischer M
Labels: Mammal;model: Human Tissue;cell: Nervous system Stress: Mitochondrial disease
Klinik für Orthopädie, Innsbruck, Austria; Email: email@example.com